Trip.com
>
Flights
>
Flights to United States
>
Flights to New York State
>
Flights to Buffalo
>
Knoxville to Buffalo flight
>
Mcghee Tyson Airport to Buffalo Niagara International Airport flight

Explore the cheapest one-way and round-trip flights from Mcghee Tyson Airport to Buffalo Niagara International Airport over the next 90 days, with one-way fares from €163 and round-trip from €216. Based on Trip.com's latest 7-day flight data.

    • Cheapest
      TYS 18:17
      5h 47m
      1 stop
      BUF 00:04
      Knoxville - Buffalo | Sun, Dec 6 | Delta Air Lines
      €163 €287
      43% off
      43% off
      €287 €163
    • TYS 18:26
      5h 28m
      1 stop
      BUF 23:54
      Knoxville - Buffalo | Sun, Dec 6 | American Airlines
      €165 €287
      43% off
      43% off
      €287 €165
    • TYS 18:07
      5h 52m
      1 stop
      BUF 23:59
      Knoxville - Buffalo | Wed, Nov 25 | Delta Air Lines
      €167 €287
      42% off
      42% off
      €287 €167
    • TYS 10:33
      6h 29m
      1 stop
      BUF 17:02
      Knoxville - Buffalo | Thu, Nov 26 | United Airlines
      €170
      41% off
      €287 €170
    • TYS 06:45
      5h 45m
      1 stop
      BUF 12:30
      Knoxville - Buffalo | Thu, Nov 26 | Hahn Air
      €175
      39% off
      €287 €175
    • TYS 17:01
      6h 38m
      1 stop
      BUF 23:39
      Knoxville - Buffalo | Tue, Nov 24 | American Airlines
      €183
      36% off
      €287 €183
    • TYS 18:13
      5h 52m
      1 stop
      BUF 00:05
      Knoxville - Buffalo | Wed, Nov 25 | American Airlines
      €190
      34% off
      €287 €190
    • TYS 05:40
      5h 26m
      1 stop
      BUF 11:06
      Knoxville - Buffalo | Thu, Nov 26 | Delta Air Lines
      €195
      32% off
      €287 €195
    • TYS 06:20
      4h 22m
      1 stop
      BUF 10:42
      Knoxville - Buffalo | Sun, Dec 6 | United Airlines
      €204
      28% off
      €287 €204
    • TYS 13:00
      17h 25m
      1 stop
      BUF 14:00
      Knoxville - Buffalo | Tue, Oct 27 | Normal Airline
      More cheap flights
      More cheap flights
    • TYS 12:42
      5h 54m
      1 stop
      BUF 18:36
      Knoxville - Buffalo | Thu, Nov 5 | American Airlines
      BUF 18:58
      3h 50m
      1 stop
      TYS 22:48
      Buffalo - Knoxville | Wed, Nov 11 | American Airlines
      €216 €379
      43% off
      43% off
      €379 €216
    • TYS 05:40
      5h 36m
      1 stop
      BUF 11:16
      Knoxville - Buffalo | Thu, Nov 5 | Delta Air Lines
      BUF 12:00
      5h 59m
      1 stop
      TYS 17:59
      Buffalo - Knoxville | Wed, Nov 11 | Delta Air Lines
      €219 €379
      42% off
      42% off
      €379 €219
    • TYS 05:40
      5h 25m
      1 stop
      BUF 11:05
      Knoxville - Buffalo | Wed, Dec 9 | Delta Air Lines
      BUF 12:11
      6h 19m
      1 stop
      TYS 18:30
      Buffalo - Knoxville | Mon, Dec 14 | Delta Air Lines
      €229 €379
      40% off
      40% off
      €379 €229
    • TYS 07:26
      4h 9m
      1 stop
      BUF 11:35
      Knoxville - Buffalo | Fri, Nov 6 | Delta Air Lines
      BUF 06:00
      4h 20m
      1 stop
      TYS 10:20
      Buffalo - Knoxville | Wed, Nov 11 | Delta Air Lines
      €250
      34% off
      €379 €250
    • TYS 05:40
      5h 26m
      1 stop
      BUF 11:06
      Knoxville - Buffalo | Sat, Nov 14 | Delta Air Lines
      BUF 10:00
      6h 45m
      1 stop
      TYS 16:45
      Buffalo - Knoxville | Mon, Nov 16 | Delta Air Lines
      €263
      31% off
      €379 €263
    • TYS 18:23
      5h 36m
      1 stop
      BUF 23:59
      Knoxville - Buffalo | Sat, Nov 7 | Delta Air Lines
      BUF 06:00
      5h 28m
      1 stop
      TYS 11:28
      Buffalo - Knoxville | Wed, Nov 11 | Delta Air Lines
      €264
      30% off
      €379 €264
    • TYS 10:55
      7h 1m
      1 stop
      BUF 17:56
      Knoxville - Buffalo | Sat, Oct 31 | American Airlines
      BUF 05:13
      5h 20m
      1 stop
      TYS 10:33
      Buffalo - Knoxville | Sun, Nov 8 | American Airlines
      €269
      28% off
      €379 €269
    • TYS 06:50
      3h 50m
      1 stop
      BUF 10:40
      Knoxville - Buffalo | Fri, Nov 13 | American Airlines
      BUF 18:58
      3h 50m
      1 stop
      TYS 22:48
      Buffalo - Knoxville | Mon, Nov 16 | American Airlines
      €271
      28% off
      €379 €271
    • TYS 12:06
      4h 3m
      1 stop
      BUF 16:09
      Knoxville - Buffalo | Thu, Oct 29 | Delta Air Lines
      BUF 06:15
      4h 5m
      1 stop
      TYS 10:20
      Buffalo - Knoxville | Sun, Nov 1 | Delta Air Lines
      €301
      21% off
      €379 €301
    • TYS 13:00
      17h 25m
      1 stop
      BUF 14:00
      Knoxville - Buffalo | Tue, Oct 27 | Normal Airline
      BUF 15:00
      6h
      Nonstop
      TYS 16:00
      Buffalo - Knoxville | Thu, Oct 29 | Normal Airline
      More cheap flights
      More cheap flights
    • TYS 06:50
      3h 52m
      1 stop
      BUF 10:42
      Knoxville - Buffalo | Thu, Nov 26 | American Airlines
      €217 €287
      24% off
      24% off
      €287 €217
    • TYS 06:50
      3h 52m
      1 stop
      BUF 10:42
      Knoxville - Buffalo | Thu, Nov 26 | American Airlines
      €236 €779
      70% off
      70% off
      €779 €236
    • TYS 07:10
      4h 1m
      1 stop
      BUF 11:11
      Knoxville - Buffalo | Thu, Nov 26 | Delta Air Lines
      €693 €779
      11% off
      11% off
      €779 €693
    • TYS 07:00
      4h 5m
      1 stop
      BUF 11:05
      Knoxville - Buffalo | Sun, Dec 6 | Delta Air Lines
      €206
      74% off
      €779 €206
    • TYS 06:20
      4h 22m
      1 stop
      BUF 10:42
      Knoxville - Buffalo | Sun, Dec 6 | United Airlines
      €204
      28% off
      €287 €204
    • TYS 05:40
      5h 26m
      1 stop
      BUF 11:06
      Knoxville - Buffalo | Thu, Nov 26 | Delta Air Lines
      €195
      32% off
      €287 €195
    • TYS 18:26
      5h 28m
      1 stop
      BUF 23:54
      Knoxville - Buffalo | Sun, Dec 6 | American Airlines
      €165
      43% off
      €287 €165
    • TYS 06:45
      5h 45m
      1 stop
      BUF 12:30
      Knoxville - Buffalo | Thu, Nov 26 | Hahn Air
      €175
      39% off
      €287 €175
    • TYS 18:17
      5h 47m
      1 stop
      BUF 00:04
      Knoxville - Buffalo | Sun, Dec 6 | Delta Air Lines
      €163
      43% off
      €287 €163
    • TYS 13:00
      17h 25m
      1 stop
      BUF 14:00
      Knoxville - Buffalo | Tue, Oct 27 | Normal Airline
      More cheap flights
      More cheap flights

Displayed flight fares from Knoxville to Buffalo are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Which airline offers the cheapest flights from Mcghee Tyson Airport to Buffalo Niagara International Airport?

The cheapest airline flying from Mcghee Tyson Airport to Buffalo Niagara International Airport is Delta Air Lines (from €163) among 4 carriers operating this route. Based on Trip.com's latest 7-day flight data.

Delta Air Lines
From €163
American Airlines
From €165
United Airlines
From €170
Hahn Air
From €175

Find more flights and airlines

What is the flight schedule from Mcghee Tyson Airport to Buffalo Niagara International Airport?

Check on the flight schedule from Knoxville to Buffalo to find the flight that matches your travel plan.

Flight info.
Departure
Arrival
Weekly Schedule

  1. AA5182

    Mcghee Tyson Airport

    09:26

    TYS

    1h 23m

    Nonstop

    10:49

    CLT

    - - - - - - S
    Search

  2. AA1203

    Charlotte Douglas International Airport

    09:08

    CLT

    1h 45m

    Nonstop

    10:53

    BUF

    S M T W T F S

  3. AA5553

    Mcghee Tyson Airport

    06:56

    TYS

    1h 24m

    Nonstop

    08:20

    CLT

    S M T W T F -
    Search

  4. AA1203

    Charlotte Douglas International Airport

    09:08

    CLT

    1h 45m

    Nonstop

    10:53

    BUF

    S M T W T F S

  5. DL1743

    Mcghee Tyson Airport

    12:00

    TYS

    1h 5m

    Nonstop

    13:05

    ATL

    S M T W T - S
    Search

  6. DL2266

    Hartsfield–Jackson Atlanta International Airport

    14:12

    ATL

    2h 1m

    Nonstop

    16:13

    BUF

    S M T W T F S

  7. UA4311

    Mcghee Tyson Airport

    05:30

    TYS

    1h 46m

    Nonstop

    07:16

    IAD

    S M T W T F S
    Search

  8. UA4018

    Dulles International Airport

    08:24

    IAD

    1h 22m

    Nonstop

    09:46

    BUF

    S - - W T - -

  9. UA4311

    Mcghee Tyson Airport

    05:30

    TYS

    1h 46m

    Nonstop

    07:16

    IAD

    S M T W T F S
    Search

  10. UA4248

    Dulles International Airport

    08:32

    IAD

    1h 22m

    Nonstop

    09:54

    BUF

    - M T - - - S

  11. DL3042

    Mcghee Tyson Airport

    19:20

    TYS

    1h 14m

    Nonstop

    20:34

    ATL

    S - - - - - -
    Search

  12. DL2334

    Hartsfield–Jackson Atlanta International Airport

    21:54

    ATL

    2h 5m

    Nonstop

    23:59

    BUF

    S M T W T F S

  13. AA5149

    Mcghee Tyson Airport

    06:00

    TYS

    2h

    Nonstop

    08:00

    DCA

    S M T W T F S
    Search

  14. AA4694

    Ronald Reagan Washington National Airport

    10:19

    DCA

    1h 32m

    Nonstop

    11:51

    BUF

    - - - - - - S

  15. DL3015

    Mcghee Tyson Airport

    05:15

    TYS

    1h 8m

    Nonstop

    06:23

    ATL

    S M T W T F S
    Search

  16. DL1384

    Hartsfield–Jackson Atlanta International Airport

    09:16

    ATL

    2h

    Nonstop

    11:16

    BUF

    S M T W T F S

  17. DL2571

    Mcghee Tyson Airport

    17:57

    TYS

    1h 8m

    Nonstop

    19:05

    ATL

    S M T W T - -
    Search

  18. DL2334

    Hartsfield–Jackson Atlanta International Airport

    21:54

    ATL

    2h 5m

    Nonstop

    23:59

    BUF

    S M T W T F S

  19. UA4581

    Mcghee Tyson Airport

    10:33

    TYS

    2h 6m

    Nonstop

    11:39

    ORD

    S M T W T - S
    Search

  20. UA2226

    O'Hare International Airport

    14:07

    ORD

    1h 47m

    Nonstop

    16:54

    BUF

    S M T W T - S
Find more flights and airlines

About Mcghee Tyson Airport and Buffalo Niagara International Airport

Learn about Mcghee Tyson Airport (TYS) and Buffalo Niagara International Airport (BUF) — including location, terminals, transportation, and travel tips.

Flight distance 912.98 km
Cheapest one-way ticket price €163
Cheapest return ticket price €216

FAQs for Mcghee Tyson Airport to Buffalo Niagara International Airport Flights

  • What are the cheapest flights from Mcghee Tyson Airport to Buffalo Niagara International Airport?

    One-way flights from Mcghee Tyson Airport to Buffalo Niagara International Airport currently start from €163, and round-trip fares start from €216. The current lowest fare is a Delta Air Lines flight departing on Sun, Dec 6; prices may vary depending on availability.
  • Based on Trip.com flight data for departures within the next 30 days with at most one stop, the average one-way price from Mcghee Tyson Airport to Buffalo Niagara International Airport is €207. Prices may vary depending on the departure date, airline, and availability.
  • Enter Mcghee Tyson Airport and Buffalo Niagara International Airport, select your departure date and number of passengers, then compare flights by price, flight duration, and baggage allowance. Once you've chosen a fare, review the change and refund rules, fill in passenger details, and pay to receive your booking confirmation.

Popular Destinations

Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

Book with no extra fees

Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.