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Cayman Islands to Panama flight

Flying From Cayman Islands to Panama: What You Need to Know

Cheapest one-way flight priceUS$398
Cheapest return ticket priceUS$402
Cheapest monthOctober
Peak season for travelJuly
Popular airlineCayman Airways

Compare multiple airlines at once to find the best flight deals from Cayman Islands to Panama.

Airlines Flying From Cayman Islands to Panama
Cayman Airways logo Cayman Airways

Search Flights From Cayman Islands to Panama

Easily compare flights from Cayman Islands to Panama and find the cheapest tickets available!

Looking for affordable flights from Cayman Islands to Panama? Check out these great prices for the next 90 days, starting at just US$398 for a one-way ticket and US$402 for a round-trip.

      • Cheapest nonstop
        Wed, Jun 10
        GCM
        PTY
        |
        Grand Cayman
        Panama City
        Nonstop | Cayman Airways
        Wed, Jun 17
        PTY
        GCM
        |
        Panama City
        Grand Cayman
        Nonstop | Cayman Airways
        US$402 US$544
        26% off
        26% off
        US$544 US$402
      • Tue, Jun 9
        GCM
        PTY
        |
        Grand Cayman
        Panama City
        1 stop | Normal Airline
        Thu, Jun 11
        PTY
        GCM
        |
        Panama City
        Grand Cayman
        Nonstop | Normal Airline
        Find more flights
        Find more flights
      • Cheapest nonstop
        Thu, Jun 18
        GCM
        PTY
        |
        Grand Cayman
        Panama City
        Nonstop | Cayman Airways
        US$398 US$538
        26% off
        26% off
        US$538 US$398
      • Tue, Jun 9
        GCM
        PTY
        |
        Grand Cayman
        Panama City
        1 stop | Normal Airline
        Find more flights
        Find more flights

Displayed flight fares from Cayman Islands to Panama are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

FAQs: Flights From Cayman Islands to Panama

  • When is it the cheapest time to fly from Cayman Islands to Panama?

    According to our flights calender over the next 90 days, the cheapest date is on 2026-06-18 for one-way flights.
  • The cheapest round-trip flight from Cayman Islands to Panama is on the route from Grand Cayman and Panama City, with prices starting at US$405 for round trip between 2026-06-26 and 2026-07-03.
  • Based on our flight data, the average flight time from Cayman Islands to Panama is approximately 2 hours based on our most popular routes from Grand Cayman to Panama City. The time may also vary depending on your destinations.
  • The cheapest airline flying to Panama from Cayman Islands is Cayman Airways serving route from Grand Cayman to Panama City.
  • Cayman Airways are airlines that fly frequently from Cayman Islands to Panama. The overall price will vary depending on your destination and travel dates.

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