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Guatemala to Panama flight

Flying From Guatemala to Panama: What You Need to Know

Cheapest one-way flight priceUS$206
Cheapest return ticket priceUS$245
Cheapest monthJanuary
Peak season for travelJuly
Popular airlineCopa Airlines

Compare multiple airlines at once to find the best flight deals from Guatemala to Panama.

Airlines Flying From Guatemala to Panama
Copa Airlines logo Copa Airlines

Search Flights From Guatemala to Panama

Easily compare flights from Guatemala to Panama and find the cheapest tickets available!

Looking for affordable flights from Guatemala to Panama? Check out these great prices for the next 90 days, starting at just US$206 for a one-way ticket and US$245 for a round-trip.

      • Cheapest nonstop
        Tue, Apr 21
        GUA
        PTY
        |
        Guatemala City
        Panama City
        Nonstop | Copa Airlines
        Tue, Apr 28
        PTY
        GUA
        |
        Panama City
        Guatemala City
        Nonstop | Copa Airlines
        US$284 US$959
        70% off
        70% off
        US$959 US$284
      • Sat, May 23
        GUA
        PTY
        |
        Guatemala City
        Panama City
        1 stop | Copa Airlines
        Sat, May 30
        PTY
        GUA
        |
        Panama City
        Guatemala City
        Nonstop | Copa Airlines
        US$245 US$959
        74% off
        74% off
        US$959 US$245
      • Thu, Apr 30
        GUA
        DAV
        |
        Guatemala City
        David
        1 stop | Copa Airlines
        Sun, May 3
        DAV
        GUA
        |
        David
        Guatemala City
        1 stop | Copa Airlines
        US$593 US$959
        38% off
        38% off
        US$959 US$593
      • Sat, Apr 18
        GUA
        BOC
        |
        Guatemala City
        Bocas Del Toro
        1 stop | Copa Airlines
        Sat, Apr 25
        BOC
        GUA
        |
        Bocas Del Toro
        Guatemala City
        1 stop | Euroairlines
        US$709
        26% off
        US$959 US$709
      • Sun, Apr 19
        GUA
        PTY
        |
        Guatemala City
        Panama City
        1 stop | Normal Airline
        Tue, Apr 21
        PTY
        GUA
        |
        Panama City
        Guatemala City
        Nonstop | Normal Airline
        Find more flights
        Find more flights
      • Cheapest nonstop
        Tue, May 12
        GUA
        PTY
        |
        Guatemala City
        Panama City
        Nonstop | Copa Airlines
        US$200 US$468
        56% off
        56% off
        US$468 US$200
      • Sat, Apr 18
        GUA
        PTY
        |
        Guatemala City
        Panama City
        1 stop | avianca
        US$206 US$468
        56% off
        56% off
        US$468 US$206
      • Sun, May 10
        FRS
        PTY
        |
        Flores
        Panama City
        1 stop | avianca
        US$229 US$468
        51% off
        51% off
        US$468 US$229
      • Fri, May 1
        GUA
        DAV
        |
        Guatemala City
        David
        1 stop | Copa Airlines
        US$232
        50% off
        US$468 US$232
      • Wed, Apr 29
        GUA
        BOC
        |
        Guatemala City
        Bocas Del Toro
        1 stop | Copa Airlines
        US$346
        26% off
        US$468 US$346
      • Sun, Apr 19
        GUA
        PTY
        |
        Guatemala City
        Panama City
        1 stop | Normal Airline
        Find more flights
        Find more flights

Displayed flight fares from Guatemala City to Panama City are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

FAQs: Flights From Guatemala to Panama

  • When is it the cheapest time to fly from Guatemala to Panama?

    According to our flights calender over the next 90 days, the cheapest date is on 2026-05-10 for one-way flights.
  • The cheapest round-trip flight from Guatemala to Panama is on the route from Guatemala City and Panama City, with prices starting at US$247 for round trip between 2026-05-07 and 2026-05-07.
  • Based on our flight data, the average flight time from Guatemala to Panama is approximately 2 hours 29 minutes based on our most popular routes from Guatemala City to Panama City. The time may also vary depending on your destinations.
  • The cheapest airline flying to Panama from Guatemala is avianca serving route from Guatemala City to Panama City.
  • Copa Airlines are airlines that fly frequently from Guatemala to Panama. The overall price will vary depending on your destination and travel dates.

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