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Flights from Chicago to Greenville

Cheapest airlines flights from Chicago to Greenville

You can choose from 1 airlines that fly from Chicago to Greenville, including American Airlines, American Airlines has lowest fares on this route.
American Airlines logo American Airlines
Airlines are determined based on actual purchased flight tickets from Chicago to Greenville according to previous 12 months data from Trip.com.

Search for direct flights from Chicago to Greenville in the next 3 months. Based on Trip.com's latest 7-day flight data, one-way direct flights start at US$173, and round-trip direct flights start at US$290.

      • Cheapest nonstop
        ORD 07:08
        2h 6m
        Nonstop
        GSP 10:14
        Chicago - Greenville | Tue, Jun 16 | United Airlines
        GSP 17:41
        2h 17m
        Nonstop
        ORD 18:58
        Greenville - Chicago | Fri, Jun 19 | United Airlines
        US$290 US$542
        46% off
        46% off
        US$542 US$290
      • ORD 18:10
        2h 7m
        Nonstop
        GSP 21:17
        Chicago - Greenville | Tue, Jun 23 | United Airlines
        GSP 06:10
        2h 19m
        Nonstop
        ORD 07:29
        Greenville - Chicago | Thu, Jun 25 | United Airlines
        US$314 US$542
        42% off
        42% off
        US$542 US$314
      • ORD 06:55
        2h
        Nonstop
        GSP 09:55
        Chicago - Greenville | Tue, Jul 7 | United Airlines
        GSP 06:10
        2h 20m
        Nonstop
        ORD 07:30
        Greenville - Chicago | Fri, Jul 10 | United Airlines
        US$331 US$542
        39% off
        39% off
        US$542 US$331
      • ORD 08:00
        2h 1m
        Nonstop
        GSP 11:01
        Chicago - Greenville | Tue, Jul 7 | American Airlines
        GSP 19:20
        2h 31m
        Nonstop
        ORD 20:51
        Greenville - Chicago | Fri, Jul 10 | American Airlines
        US$348
        36% off
        US$542 US$348
      • ORD 20:49
        1h 59m
        Nonstop
        GSP 23:48
        Chicago - Greenville | Tue, Jun 23 | American Airlines
        GSP 07:20
        2h 26m
        Nonstop
        ORD 08:46
        Greenville - Chicago | Thu, Jun 25 | American Airlines
        US$349
        36% off
        US$542 US$349
      • ORD 08:00
        2h 4m
        Nonstop
        GSP 11:04
        Chicago - Greenville | Tue, Jun 16 | American Airlines
        GSP 18:41
        2h 34m
        Nonstop
        ORD 20:15
        Greenville - Chicago | Fri, Jun 19 | American Airlines
        US$388
        28% off
        US$542 US$388
      • ORD 09:48
        5h 22m
        1 stop
        GSP 16:10
        Chicago - Greenville | Tue, Jul 7 | Delta Air Lines
        GSP 07:10
        4h 40m
        1 stop
        ORD 10:50
        Greenville - Chicago | Fri, Jul 10 | Delta Air Lines
        US$289
        47% off
        US$542 US$289
      • ORD 06:35
        4h 43m
        1 stop
        GSP 12:18
        Chicago - Greenville | Tue, Jun 23 | Delta Air Lines
        GSP 07:10
        6h 36m
        1 stop
        MDW 12:46
        Greenville - Chicago | Thu, Jun 25 | Delta Air Lines
        US$290
        46% off
        US$542 US$290
      • ORD 14:07
        6h 41m
        1 stop
        GSP 21:48
        Chicago - Greenville | Tue, Jun 16 | Delta Air Lines
        GSP 17:16
        6h 1m
        1 stop
        MDW 22:17
        Greenville - Chicago | Fri, Jun 19 | Delta Air Lines
        US$294
        46% off
        US$542 US$294
      • CHI 13:00
        17h 25m
        1 stop
        GSP 14:00
        Chicago - Greenville | Sat, Jun 13 | Normal Airline
        GSP 15:00
        6h
        Nonstop
        CHI 16:00
        Greenville - Chicago | Mon, Jun 15 | Normal Airline
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      • Cheapest nonstop
        ORD 20:49
        1h 59m
        Nonstop
        GSP 23:48
        Chicago - Greenville | Wed, Jun 24 | American Airlines
        US$173 US$273
        37% off
        37% off
        US$273 US$173
      • ORD 20:49
        1h 59m
        Nonstop
        GSP 23:48
        Chicago - Greenville | Thu, Jun 25 | American Airlines
        US$211 US$273
        23% off
        23% off
        US$273 US$211
      • ORD 06:55
        2h
        Nonstop
        GSP 09:55
        Chicago - Greenville | Thu, Jun 25 | United Airlines
        US$213 US$273
        22% off
        22% off
        US$273 US$213
      • ORD 18:10
        2h 7m
        Nonstop
        GSP 21:17
        Chicago - Greenville | Fri, Jun 19 | United Airlines
        US$214
        22% off
        US$273 US$214
      • ORD 06:55
        2h
        Nonstop
        GSP 09:55
        Chicago - Greenville | Sun, Jun 28 | United Airlines
        US$215
        21% off
        US$273 US$215
      • ORD 05:30
        4h 29m
        1 stop
        GSP 10:59
        Chicago - Greenville | Wed, Jun 24 | Delta Air Lines
        US$139
        49% off
        US$273 US$139
      • ORD 08:40
        4h 40m
        1 stop
        GSP 14:20
        Chicago - Greenville | Wed, Jun 24 | United Airlines
        US$170
        38% off
        US$273 US$170
      • ORD 05:30
        5h 48m
        1 stop
        GSP 12:18
        Chicago - Greenville | Thu, Jun 25 | Delta Air Lines
        US$208
        24% off
        US$273 US$208
      • CHI 13:00
        17h 25m
        1 stop
        GSP 14:00
        Chicago - Greenville | Sat, Jun 13 | Normal Airline
        Find more flights
        Find more flights

Displayed flight fares from Chicago to Greenville are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Chicago to Greenville Flight Details

The distance between Chicago and Greenville is about 905.15 km. The average flying time from Chicago to Greenville is around 2 hours 4 minutes. Based on Trip.com's latest data, travel demand is highest in July. The off-season for travel is October.

Cheapest one-way flight priceUS$139
Cheapest return ticket priceUS$289
Cheapest monthOctober
Peak season for travelJuly
Flight distance905.15 km
Average flight time2 hours 4 minutes
Popular airlineAmerican Airlines
Flight statistics for the Chicago–Greenville route are based on aggregated booking data from Trip.com over the past 12 months.

Frequently Asked Questions

  • What are the cheapest flights from Chicago to Greenville (CHI-GSP)?

    Based on Trip.com data, Delta Air Lines offers one-way fares as low as US$139 on Cheapest nonstop routes (e.g. ORD to GSP on Wed, Jun 24), while Delta Air Lines offers Cheapest nonstop round-trips from US$289 departing on Tue, Jul 7 and returning on Fri, Jul 10.
  • It takes about 2 hours 4 minutes to fly from Chicago to Greenville.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Chicago to Greenville is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Chicago to Greenville, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Jun 24, with one-way flights priced at just US$139.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is American Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Greenville travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Chicago to Greenville is October, when demand for travel is lower.
  • After crunching the numbers on our June flight calendar, it's currently cheapest to fly from Chicago to Greenville on June 30, 2026 with American Airlines, with prices starting at US$261.
  • The time difference between Greenville and Chicago is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Trip.com Airline Insights on Flights from Chicago to Greenville

Which airline offers the cheapest direct flights from Chicago to Greenville?

Data is based on the average price of all nonstop flights from Chicago to Greenville on Trip.com over the past 12 months.

Based on Trip.com’s data from the past 12 months, American Airlines provides the lowest-priced direct flights from Chicago to Greenville, with fares starting at US$255.

US$230
US$255
US$280
US$305
US$330
American Airlines
US$255
American Airlines
Delta Air Lines
US$306
Delta Air Lines
United Airlines
US$330
United Airlines

Which airline operates the most flights from Chicago to Greenville?

Total flights from Chicago to Greenville across all airlines. (Based on Trip.com data from the past month)

Based on Trip.com’s data from the past month, Air New Zealand/Air Canada/United Airlines operates the most frequent flights from Chicago to Greenville, with 26 flights per week.

10
15
21
26
Air New Zealand
26
Air New Zealand
Air Canada
26
Air Canada
United Airlines
26
United Airlines
Alaska Airlines
23
Alaska Airlines
American Airlines
23
American Airlines
All Nippon Airways
15
All Nippon Airways

How many flights fly from Chicago to Greenville daily?

The data is based on the flight numbers for each day of the week from Chicago to Greenville within the Trip.com database over the past month.

Based on the past month's historical data from Trip.com, the number of flights from Chicago to Greenville is the highest on Saturday and the lowest on Tuesday/Thursday.

109
97
84
72
Highest
88
Mon
84
Tue
88
Wed
84
Thu
107
Fri
109
Sat
100
Sun

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Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

Book with no extra fees

Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.