Trip.com
>
Flights
>
Flights to United States
>
Flights to Missouri
>
Flights to Cape Girardeau
Hotels in Cape Girardeau
>
Flights from Des Moines to Cape Girardeau

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

      • DSM 18:46
        18h 39m
        1 stop
        CGI 13:25
        Des Moines - Cape Girardeau | Sat, Dec 27 | United Airlines
        CGI 09:30
        5h 3m
        1 stop
        DSM 14:33
        Cape Girardeau - Des Moines | Sat, Jan 3 | Contour Airlines
        €515 €579
        11% OFF
        11% OFF
        €579 €515
      • DSM 13:00
        17h 25m
        1 stop
        CGI Invalid Date
        Des Moines - Cape Girardeau | Fri, Dec 12 | Normal Airline
        CGI 15:00
        6h
        Nonstop
        DSM 16:00
        Cape Girardeau - Des Moines | Sun, Dec 14 | Normal Airline
        Find More Flights
        Find More Flights

Displayed flight fares from Des Moines to Cape Girardeau are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Des Moines to Cape Girardeau Flight Details

The distance between Des Moines and Cape Girardeau is about 593.93 km. Based on Trip.com's latest data, travel demand is highest in December. The off-season for travel is February.

Cheapest return ticket price€515
Cheapest monthFebruary
Peak season for travelDecember
Flight distance593.93 km

When is the cheapest time to book flights from Des Moines to Cape Girardeau?

The cheapest time to fly from Des Moines to Cape Girardeau: Dec 21 to Dec 28 — one-way prices start at €515.

Cheapest flights
From price
Search
  • 714
  • 1421
  • 2128

  • Jan

    284
  • 411
  • 1118
  • 1825

  • Feb

    251
  • 18
  • 815
  • 1522

  • Mar

    221
Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • When is the best time to book flights from Des Moines to Cape Girardeau?

    By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Des Moines to Cape Girardeau is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Des Moines to Cape Girardeau, you can use various tools on Trip.com:
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Cape Girardeau travel is around December.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Des Moines to Cape Girardeau is February, when demand for travel is lower.
  • After crunching the numbers on our December flight calendar, it's currently cheapest to fly from Des Moines to Cape Girardeau on December 27, 2025 with United Airlines, with prices starting at €514.
  • The time difference between Cape Girardeau and Des Moines is 0h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Explore More Popular Flights