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Flights from Indianapolis to St. Louis

Search cheap flights from Indianapolis to St. Louis in the next 3 months. Based on Trip.com's latest 7-day data, one-way fares start at US$93, and round-trip tickets start at US$218.

      • IND 06:00
        4h 44m
        1 stop
        STL 09:44
        Indianapolis - St. Louis | Fri, May 22 | Delta Air Lines
        STL 06:45
        5h 42m
        1 stop
        IND 13:27
        St. Louis - Indianapolis | Sat, May 23 | Delta Air Lines
        US$218 US$424
        49% off
        49% off
        US$424 US$218
      • IND 11:03
        4h
        1 stop
        STL 14:03
        Indianapolis - St. Louis | Fri, May 22 | American Airlines
        STL 05:51
        3h 32m
        1 stop
        IND 10:23
        St. Louis - Indianapolis | Sat, May 23 | American Airlines
        US$219 US$424
        48% off
        48% off
        US$424 US$219
      • IND 13:44
        5h 34m
        1 stop
        STL 18:18
        Indianapolis - St. Louis | Mon, Jun 15 | Frontier Airlines
        STL 06:21
        4h 19m
        1 stop
        IND 11:40
        St. Louis - Indianapolis | Wed, Jun 17 | Delta Air Lines
        US$282 US$424
        33% off
        33% off
        US$424 US$282
      • IND 06:30
        3h 59m
        1 stop
        STL 09:29
        Indianapolis - St. Louis | Sat, May 30 | Delta Air Lines
        STL 17:15
        6h 18m
        1 stop
        IND 00:33
        St. Louis - Indianapolis | Sat, Jun 6 | Delta Air Lines
        US$284
        33% off
        US$424 US$284
      • IND 06:00
        4h 44m
        1 stop
        STL 09:44
        Indianapolis - St. Louis | Sat, May 23 | Delta Air Lines
        STL 18:57
        4h 36m
        1 stop
        IND 00:33
        St. Louis - Indianapolis | Sat, May 30 | Delta Air Lines
        US$288
        32% off
        US$424 US$288
      • IND 05:10
        4h 22m
        1 stop
        STL 08:32
        Indianapolis - St. Louis | Sat, May 30 | American Airlines
        STL 07:00
        3h 31m
        1 stop
        IND 11:31
        St. Louis - Indianapolis | Sat, Jun 6 | American Airlines
        US$289
        32% off
        US$424 US$289
      • IND 06:00
        3h 39m
        1 stop
        STL 08:39
        Indianapolis - St. Louis | Fri, May 22 | United Airlines
        STL 05:35
        5h 30m
        1 stop
        IND 12:05
        St. Louis - Indianapolis | Sat, May 23 |
        US$294
        31% off
        US$424 US$294
      • IND 19:38
        5h 6m
        1 stop
        STL 23:44
        Indianapolis - St. Louis | Thu, Jun 4 | American Airlines
        STL 06:00
        4h 30m
        1 stop
        IND 11:30
        St. Louis - Indianapolis | Thu, Jun 11 | American Airlines
        US$303
        28% off
        US$424 US$303
      • IND 06:40
        3h 52m
        1 stop
        STL 09:32
        Indianapolis - St. Louis | Sun, Jun 14 | Delta Air Lines
        STL 10:20
        4h
        1 stop
        IND 15:20
        St. Louis - Indianapolis | Sat, Jun 20 | Delta Air Lines
        US$305
        28% off
        US$424 US$305
      • IND 19:33
        4h 50m
        1 stop
        STL 23:23
        Indianapolis - St. Louis | Fri, Jun 19 | Delta Air Lines
        STL 18:10
        5h
        1 stop
        IND 00:10
        St. Louis - Indianapolis | Sun, Jun 21 | Delta Air Lines
        US$305
        28% off
        US$424 US$305
      • IND 13:00
        17h 25m
        1 stop
        STL 14:00
        Indianapolis - St. Louis | Sat, May 23 | Normal Airline
        STL 15:00
        6h
        Nonstop
        IND 16:00
        St. Louis - Indianapolis | Mon, May 25 | Normal Airline
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      • IND 13:44
        5h 34m
        1 stop
        STL 18:18
        Indianapolis - St. Louis | Sat, Jun 13 | Frontier Airlines
        US$93 US$205
        55% off
        55% off
        US$205 US$93
      • IND 06:00
        4h 44m
        1 stop
        STL 09:44
        Indianapolis - St. Louis | Fri, May 22 | Delta Air Lines
        US$133 US$205
        35% off
        35% off
        US$205 US$133
      • IND 17:01
        5h 37m
        1 stop
        STL 21:38
        Indianapolis - St. Louis | Sat, May 23 | Delta Air Lines
        US$133 US$205
        35% off
        35% off
        US$205 US$133
      • IND 06:00
        4h 44m
        1 stop
        STL 09:44
        Indianapolis - St. Louis | Sat, Jun 6 | Delta Air Lines
        US$135
        34% off
        US$205 US$135
      • IND 16:58
        16h 18m
        1 stop
        STL 08:16
        Indianapolis - St. Louis | Tue, Jun 9 | Delta Air Lines
        US$138
        33% off
        US$205 US$138
      • IND 06:00
        4h 44m
        1 stop
        STL 09:44
        Indianapolis - St. Louis | Sat, May 30 | Delta Air Lines
        US$138
        33% off
        US$205 US$138
      • IND 06:00
        4h 44m
        1 stop
        STL 09:44
        Indianapolis - St. Louis | Fri, Jun 5 | Delta Air Lines
        US$139
        32% off
        US$205 US$139
      • IND 15:40
        6h 38m
        1 stop
        STL 21:18
        Indianapolis - St. Louis | Sat, May 23 | United Airlines
        US$140
        32% off
        US$205 US$140
      • IND 19:59
        5h
        1 stop
        STL 23:59
        Indianapolis - St. Louis | Sun, Jun 7 | Delta Air Lines
        US$146
        28% off
        US$205 US$146
      • IND 06:00
        4h 46m
        1 stop
        STL 09:46
        Indianapolis - St. Louis | Sat, Jun 13 | Delta Air Lines
        US$147
        28% off
        US$205 US$147
      • IND 13:00
        17h 25m
        1 stop
        STL 14:00
        Indianapolis - St. Louis | Sat, May 23 | Normal Airline
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Displayed flight fares from Indianapolis to St. Louis are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Frequently Asked Questions

  • What are the cheapest flights from Indianapolis to St. Louis (IND-STL)?

    Based on Trip.com data, Frontier Airlines offers one-way fares as low as US$93 on Cheapest nonstop routes (e.g. IND to STL on Sat, Jun 13), while Delta Air Lines offers Cheapest nonstop round-trips from US$218 departing on Fri, May 22 and returning on Sat, May 23.
  • At the moment, you can catch a nonstop flight from Indianapolis to St. Louis with the following airlines, including: United Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Indianapolis to St. Louis is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 1 flight per week flying from Indianapolis to St. Louis. You can check the weekly schedule for popular airlines on this route below: United Airlines: -/-/-/-/-/-/- -- UA4394 (01:21)
  • To find best deals on flights from Indianapolis to St. Louis, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Sat, Jun 13, with one-way flights priced at just US$93.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Frontier Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for St. Louis travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Indianapolis to St. Louis is October, when demand for travel is lower.
  • After crunching the numbers on our May flight calendar, it's currently cheapest to fly from Indianapolis to St. Louis on May 27, 2026 with Delta Air Lines, with prices starting at US$138.
  • You can land at any one of the following hubs in St. Louis, with Indianapolis International Airport to St. Louis Lambert International Airport (IND-STL) is by far the most common option on this route: St. Louis Downtown Airport (CPS) St. Louis Lambert International Airport (STL).
  • The time difference between St. Louis and Indianapolis is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

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Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.