US$227️ Cheap Flights from Knoxville to Des Moines (2024)

App

Help

USD

Search Bookings

Trip.com

Flights

Flights to United States

Flights to Des Moines

Flights from Knoxville to Des Moines

Hotels in Des Moines

Worldwide Coverage

Flights to over 5,000 cities

One-stop Service Guarantee

Price guaranteed upon confirmed payment, booking guaranteed once tickets issued

Secure Payment

Convenient & reliable booking and payment system

Knoxville to Des Moines - Flights Starting at US$227

Book one-way or return flights from Knoxville to Des Moines from as little as US$227. Choose from the popular airlines below and book your flight today!

One way
Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

We've found these cheap flights for you. You may book a one-way or round trip as per your needs.

We monitor flight fares to help you seize the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Cheapest airlines flights from Knoxville to Des Moines

View airlines operating flights from Knoxville to Des Moines. Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Frontier Airlines

From US$227

Delta Air Lines

From US$244

American Airlines

From US$275

United Airlines

From US$295

ANA airlines

Find more flights and airlines

Alternative Routes from Knoxville to Des Moines

Discover different routes, airlines, and transfers and find the best alternative flights for your journey from Knoxville to Des Moines.

Cheapest
TYS
18:38
27h 10m
1 transfer
DSM
20:48
Mcghee Tyson Airport - Des Moines International Airport
Mon, May 20Frontier Airlines
US$227
TYS
18:38
27h 10m
1 transfer
DSM
20:48
Mcghee Tyson Airport - Des Moines International Airport
Mon, May 20Frontier Airlines
US$227
Find More Flights

Frequently Asked Questions

When are flight tickets from Knoxville (TYS) to Des Moines (DSM) the cheapest?
Airlines adjust prices for flights from Knoxville to Des Moines based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
How much do flights from Knoxville (TYS) to Des Moines (DSM) cost?
According to Trip.com's data, the lowest price is around $493.

How to find a cheap flight from Knoxville to Des Moines

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Knoxville to Des Moines. Book your flights at the right time and save more.

Book Early

Once prices are gone, they're gone. Lock in deals while you can!

Compare Flight Prices

Compare prices on travel agency and airline websites.

Look Out for Deals

Check airline and travel agency websites for latest flight deals

Check One-way Fares

Buying two cheap one-way flights can sometimes be a better deal than a round-trip.

Try Different Dates

Flying during the week, early in the morning, or late at night can help save money.

Use the Trip.com App

Save up to £10 per person when booking your flights on Trip.com