Cheapest airlines flights from Madrid to Brussels

You can choose from 5 airlines that fly from Madrid to Brussels, including Air Europa, Ryanair, and Iberia. Ryanair has lowest fares on this route.
Air Europa logo Air Europa
Ryanair logo Ryanair
Iberia logo Iberia
Brussels Airlines logo Brussels Airlines
TAP Air Portugal logo TAP Air Portugal
Airlines are determined based on actual purchased flight tickets from Madrid to Brussels according to previous 12 months data from Trip.com.

Search for direct flights from Madrid to Brussels in the next 3 months. Based on Trip.com's latest 7-day flight data, one-way direct flights start at US$24, and round-trip direct flights start at US$48.

Displayed flight fares from Madrid to Brussels are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Madrid to Brussels Flight Details

The distance between Madrid and Brussels is about 1,316.38 km. The average flying time from Madrid to Brussels is around 2 hours 25 minutes. Based on Trip.com's latest data, travel demand is highest in July. The off-season for travel is October.

Cheapest one-way flight priceUS$24
Cheapest return ticket priceUS$48
Cheapest monthOctober
Peak season for travelJuly
Flight distance1,316.38 km
Average flight time2 hours 25 minutes
Popular airlineAir Europa
Flight statistics for the Madrid–Brussels route are based on aggregated booking data from Trip.com over the past 12 months.

Trip.com Price Insights on Flights from Madrid to Brussels

Which month has the cheapest one-way flights from Madrid to Brussels?

The average price of one-way flights from Madrid to Brussels purchased by Trip.com users by month over the past 12 months.

Based on Trip.com’s data, the cheapest month for flights from Madrid to Brussels is Feb, with an average price of US$83; while the month with the highest flight price is usually Aug, with an average price of up to US$199.

US$199
US$141
US$83
US$25
  • US$83
    Feb
  • US$103
    Mar
  • US$149
    Apr
  • US$129
    May
  • US$132
    Jun
  • US$116
    Jul
  • US$199
    Aug
  • US$138
    Sep
  • US$148
    Oct
  • US$134
    Nov
  • US$107
    Dec
  • US$127
    Jan

Which month has the cheapest round-trip flights from Madrid to Brussels?

The average price of round-trip flights from Madrid to Brussels purchased by Trip.com users by month over the past 12 months.

Based on data from Trip.com, the lowest prices for round-trip flights from Madrid to Brussels are found during Feb, with an average price of US$173. Conversely, the highest prices are found during Jul, with an average price of up to US$278.

US$278
US$226
US$173
US$121
  • US$173
    Feb
  • US$180
    Mar
  • US$250
    Apr
  • US$218
    May
  • US$233
    Jun
  • US$278
    Jul
  • US$259
    Aug
  • US$217
    Sep
  • US$247
    Oct
  • US$218
    Nov
  • US$214
    Dec
  • US$184
    Jan

What is the cheapest day of the week to fly from Madrid to Brussels?

Average weekly flight prices from Madrid to Brussels by travel date (Based on Trip.com’s past 12 months of data)

Based on Trip.com’s past 12 months of flight data, the cheapest day to fly from Madrid to Brussels is Thu, with average prices lower than on other days. Avoid Sun, as prices are usually highest then.

US$155
US$138
US$121
US$104
    Cheapest
  • US$132
    Mon
  • US$127
    Tue
  • US$124
    Wed
  • US$121
    Thu
  • US$128
    Fri
  • US$123
    Sat
  • US$155
    Sun

Frequently Asked Questions

  • What are the cheapest flights from Madrid to Brussels (MAD-BRU)?

    Based on Trip.com data, Ryanair offers one-way fares as low as US$24 on Cheapest nonstop routes (e.g. MAD to CRL on Mon, Mar 16), while Ryanair offers Cheapest nonstop round-trips from US$48 departing on Tue, Mar 10 and returning on Thu, Mar 12.
  • At the moment, you can catch a nonstop flight from Madrid to Brussels with the following airlines, including: Air Europa Ryanair Iberia Brussels Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • It takes about 2 hours 25 minutes to fly from Madrid to Brussels.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Madrid to Brussels is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 57 flight per week flying from Madrid to Brussels. You can check the weekly schedule for popular airlines on this route below: Iberia: S/M/T/W/T/F/S -- IB597 (10:28)
  • To find best deals on flights from Madrid to Brussels, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Mon, Mar 16, with one-way flights priced at just US$24.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Ryanair.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Brussels travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Madrid to Brussels is October, when demand for travel is lower.
  • After crunching the numbers on our February flight calendar, it's currently cheapest to fly from Madrid to Brussels on February 18, 2026 with Ryanair, with prices starting at US$24.
  • You can land at any one of the following hubs in Brussels, with Madrid Barajas Airport to Brussels Airport (MAD-BRU) is by far the most common option on this route: Brussels Airport (BRU) Brussels South Charleroi Airport (CRL).
  • The time difference between Brussels and Madrid is 0h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Trip.com Airline Insights on Flights from Madrid to Brussels

Which airline offers the cheapest direct flights from Madrid to Brussels?

Data is based on the average price of all nonstop flights from Madrid to Brussels on Trip.com over the past 12 months.

Based on Trip.com’s data from the past 12 months, Ryanair provides the lowest-priced direct flights from Madrid to Brussels, with fares starting at US$101.

US$30
US$101
US$172
US$243
US$314
Ryanair
US$101
Ryanair
TAP Air Portugal
US$111
TAP Air Portugal
Air Europa
US$151
Air Europa
Iberia
US$182
Iberia
Brussels Airlines
US$198
Brussels Airlines
Vueling Airlines
US$314
Vueling Airlines

Which airline operates the most flights from Madrid to Brussels?

Total flights from Madrid to Brussels across all airlines. (Based on Trip.com data from the past month)

Based on Trip.com’s data from the past month, Iberia operates the most frequent flights from Madrid to Brussels, with 27 flights per week.

14
18
23
27
Iberia
27
Iberia
Vueling Airlines
26
Vueling Airlines
LATAM Airlines
22
LATAM Airlines
American Airlines
21
American Airlines
Etihad Airways
20
Etihad Airways
Brussels Airlines
18
Brussels Airlines

How many flights fly from Madrid to Brussels daily?

The data is based on the flight numbers for each day of the week from Madrid to Brussels within the Trip.com database over the past month.

Based on the past month's historical data from Trip.com, the number of flights from Madrid to Brussels is the highest on Monday and the lowest on Wednesday.

146
131
115
100
Highest
146
Mon
140
Tue
115
Wed
136
Thu
140
Fri
139
Sat
138
Sun