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Flights from Medellin to Antofagasta

Cheapest airlines flights from Medellin to Antofagasta

Fly from Medellin to Antofagasta with 1 carriers, including JetSMART Airlines, JetSMART Airlines offers the cheapest flights from Medellin to Antofagasta.
JetSMART Airlines logo JetSMART Airlines

Find Medellin to Antofagasta flight deals for the next 3 months. One way flights from US$170, round trip flights from US$371.

      • MDE 17:59
        8h 11m
        1 stop
        ANF 04:10
        Medellin - Antofagasta | Wed, Nov 19 | LATAM Airlines
        ANF 06:05
        12h 10m
        1 stop
        MDE 16:15
        Antofagasta - Medellin | Tue, Nov 25 | LATAM Airlines
        US$371 US$560
        34% OFF
        34% OFF
        US$560 US$371
      • MDE 06:27
        11h 9m
        1 stop
        ANF 19:36
        Medellin - Antofagasta | Mon, Dec 29 | JetSMART Airlines
        ANF 20:58
        11h 16m
        1 stop
        MDE 06:14
        Antofagasta - Medellin | Tue, Jan 6 | JetSMART Airlines
        US$437 US$560
        22% OFF
        22% OFF
        US$560 US$437
      • MDE 04:40
        12h 56m
        1 stop
        ANF 19:36
        Medellin - Antofagasta | Mon, Dec 29 | LATAM Airlines
        ANF 20:58
        11h 16m
        1 stop
        MDE 06:14
        Antofagasta - Medellin | Tue, Jan 6 | JetSMART Airlines
        US$459 US$560
        18% OFF
        18% OFF
        US$560 US$459
      • MDE 06:05
        11h 31m
        1 stop
        ANF 19:36
        Medellin - Antofagasta | Tue, Dec 30 | JetSMART Airlines
        ANF 21:59
        10h 15m
        1 stop
        MDE 06:14
        Antofagasta - Medellin | Sun, Jan 4 | JetSMART Airlines
        US$473
        16% OFF
        US$560 US$473
      • MDE 06:05
        11h 31m
        1 stop
        ANF 19:36
        Medellin - Antofagasta | Tue, Dec 2 | JetSMART Airlines
        ANF 09:30
        7h 25m
        1 stop
        MDE 14:55
        Antofagasta - Medellin | Tue, Dec 9 | JetSMART Airlines
        US$481
        14% OFF
        US$560 US$481
      • EOH 07:00
        10h 36m
        1 stop
        ANF 19:36
        Medellin - Antofagasta | Mon, Dec 29 | EasyFly
        ANF 20:58
        11h 16m
        1 stop
        MDE 06:14
        Antofagasta - Medellin | Tue, Jan 6 | JetSMART Airlines
        US$492
        12% OFF
        US$560 US$492
      • MDE 06:45
        10h 51m
        1 stop
        ANF 19:36
        Medellin - Antofagasta | Mon, Dec 1 | JetSMART Airlines
        ANF 21:45
        10h 29m
        1 stop
        MDE 06:14
        Antofagasta - Medellin | Sun, Dec 7 | JetSMART Airlines
        US$493
        12% OFF
        US$560 US$493
      • MDE 04:55
        12h 41m
        1 stop
        ANF 19:36
        Medellin - Antofagasta | Tue, Dec 30 | avianca
        ANF 21:59
        10h 15m
        1 stop
        MDE 06:14
        Antofagasta - Medellin | Sun, Jan 4 | JetSMART Airlines
        US$514
        8% OFF
        US$560 US$514
      • EOH 07:00
        10h 36m
        1 stop
        ANF 19:36
        Medellin - Antofagasta | Tue, Dec 30 | EasyFly
        ANF 21:59
        10h 15m
        1 stop
        MDE 06:14
        Antofagasta - Medellin | Sun, Jan 4 | JetSMART Airlines
        US$517
        8% OFF
        US$560 US$517
      • MDE 04:40
        12h 56m
        1 stop
        ANF 19:36
        Medellin - Antofagasta | Tue, Dec 2 | LATAM Airlines
        ANF 09:30
        7h 25m
        1 stop
        MDE 14:55
        Antofagasta - Medellin | Tue, Dec 9 | JetSMART Airlines
        US$527
        6% OFF
        US$560 US$527
      • MDE 13:00
        17h 25m
        1 stop
        ANF Invalid Date
        Medellin - Antofagasta | Fri, Nov 21 | Normal Airline
        ANF 15:00
        6h
        Nonstop
        MDE 16:00
        Antofagasta - Medellin | Sun, Nov 23 | Normal Airline
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Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Medellin to Antofagasta Flight Information

The distance between Medellin and Antofagasta is approximately 3,346.88 km. The most popular month to fly to Antofagasta is July. The off-season for travel is October.

Cheapest one-way flight priceUS$170
Cheapest return ticket priceUS$371
Cheapest monthOctober
Peak season for travelJuly
Flight distance3,346.88 km
Popular airlineJetSMART

When is the cheapest time to book flights from Medellin to Antofagasta?

Best time for cheap flights from Medellin to Antofagasta are between Nov 30 and Dec 7 with one way fares from US$170

Cheapest flights
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  • Dec

    307
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  • 1421
  • 2128

  • Jan

    284
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  • 1118
  • 1825

  • Feb

    251
  • 18
Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • Which airlines offer direct flights from Medellin to Antofagasta?

    At the moment, you can catch a nonstop flight from Medellin to Antofagasta with the following airlines, including: JetSMART Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Medellin to Antofagasta is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • The cheapest months to fly from Medellin to Antofagasta is October, when demand for travel is lower.
  • After crunching the numbers on our November flight calendar, it's currently cheapest to fly from Medellin to Antofagasta on November 22, 2025 with JetSMART, with prices starting at US$190.
  • You can land at any one of the following hubs in Antofagasta, with Jose Maria Cordova International Airport to Andres Sabella Airport (MDE-ANF) is by far the most common option on this route: Andres Sabella Airport (ANF).
  • The time difference between Antofagasta and Medellin is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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