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Flights from Medellin to Santo Domingo

Search for direct flights from Medellin to Santo Domingo in the next 3 months. Based on Trip.com's latest 7-day flight data, one-way direct flights start at US$134, and round-trip direct flights start at US$247.

      • Cheapest nonstop
        MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Sat, May 23 | DM Airlines
        SDQ 14:10
        2h 32m
        Nonstop
        MDE 15:42
        Santo Domingo - Medellin | Wed, May 27 | DM Airlines
        US$247 US$353
        30% off
        30% off
        US$353 US$247
      • MDE 10:05
        2h 32m
        Nonstop
        SDQ 13:37
        Medellin - Santo Domingo | Fri, Jun 12 | DM Airlines
        SDQ 07:45
        2h 35m
        Nonstop
        MDE 09:20
        Santo Domingo - Medellin | Wed, Jun 17 | DM Airlines
        US$248 US$353
        30% off
        30% off
        US$353 US$248
      • MDE 10:05
        2h 32m
        Nonstop
        SDQ 13:37
        Medellin - Santo Domingo | Sat, May 30 | DM Airlines
        SDQ 14:10
        2h 32m
        Nonstop
        MDE 15:42
        Santo Domingo - Medellin | Wed, Jun 3 | DM Airlines
        US$248 US$353
        30% off
        30% off
        US$353 US$248
      • MDE 10:05
        2h 32m
        Nonstop
        SDQ 13:37
        Medellin - Santo Domingo | Fri, May 29 | DM Airlines
        SDQ 16:35
        2h 35m
        Nonstop
        MDE 18:10
        Santo Domingo - Medellin | Mon, Jun 1 | DM Airlines
        US$248
        30% off
        US$353 US$248
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Sat, Jun 13 | DM Airlines
        SDQ 07:45
        2h 35m
        Nonstop
        MDE 09:20
        Santo Domingo - Medellin | Wed, Jun 17 | DM Airlines
        US$253
        28% off
        US$353 US$253
      • MDE 10:05
        2h 32m
        Nonstop
        SDQ 13:37
        Medellin - Santo Domingo | Wed, Jun 3 | DM Airlines
        SDQ 18:05
        2h 35m
        Nonstop
        MDE 19:40
        Santo Domingo - Medellin | Tue, Jun 9 | DM Airlines
        US$254
        28% off
        US$353 US$254
      • MDE 10:05
        2h 32m
        Nonstop
        SDQ 13:37
        Medellin - Santo Domingo | Fri, Jun 5 | DM Airlines
        SDQ 16:35
        2h 35m
        Nonstop
        MDE 18:10
        Santo Domingo - Medellin | Mon, Jun 8 | DM Airlines
        US$256
        27% off
        US$353 US$256
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Thu, Jun 4 | DM Airlines
        SDQ 16:35
        2h 35m
        Nonstop
        MDE 18:10
        Santo Domingo - Medellin | Mon, Jun 8 | DM Airlines
        US$256
        27% off
        US$353 US$256
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Sat, Jun 20 | DM Airlines
        SDQ 18:05
        2h 35m
        Nonstop
        MDE 19:40
        Santo Domingo - Medellin | Tue, Jun 23 | DM Airlines
        US$257
        27% off
        US$353 US$257
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Sat, May 16 | DM Airlines
        SDQ 07:45
        2h 35m
        Nonstop
        MDE 09:20
        Santo Domingo - Medellin | Sun, May 24 | DM Airlines
        US$257
        27% off
        US$353 US$257
      • MDE 13:00
        17h 25m
        1 stop
        SDQ 14:00
        Medellin - Santo Domingo | Wed, May 13 | Normal Airline
        SDQ 15:00
        6h
        Nonstop
        MDE 16:00
        Santo Domingo - Medellin | Fri, May 15 | Normal Airline
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      • Cheapest nonstop
        MDE 10:05
        2h 32m
        Nonstop
        SDQ 13:37
        Medellin - Santo Domingo | Wed, Jun 3 | DM Airlines
        US$134 US$322
        57% off
        57% off
        US$322 US$134
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Thu, May 14 | DM Airlines
        US$143 US$322
        56% off
        56% off
        US$322 US$143
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Tue, Jun 2 | DM Airlines
        US$143 US$322
        56% off
        56% off
        US$322 US$143
      • MDE 19:00
        2h 32m
        Nonstop
        SDQ 22:32
        Medellin - Santo Domingo | Mon, Jun 1 | DM Airlines
        US$143
        56% off
        US$322 US$143
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Sat, May 30 | DM Airlines
        US$145
        55% off
        US$322 US$145
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Sat, Jun 20 | DM Airlines
        US$146
        55% off
        US$322 US$146
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Thu, Jun 4 | DM Airlines
        US$150
        53% off
        US$322 US$150
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Sat, Jun 13 | DM Airlines
        US$158
        51% off
        US$322 US$158
      • MDE 10:05
        2h 32m
        Nonstop
        SDQ 13:37
        Medellin - Santo Domingo | Sat, May 23 | DM Airlines
        US$189
        41% off
        US$322 US$189
      • MDE 20:25
        2h 32m
        Nonstop
        SDQ 23:57
        Medellin - Santo Domingo | Tue, May 26 | DM Airlines
        US$235
        27% off
        US$322 US$235
      • MDE 13:00
        17h 25m
        1 stop
        SDQ 14:00
        Medellin - Santo Domingo | Wed, May 13 | Normal Airline
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Displayed flight fares from Medellin to Santo Domingo are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Trip.com Price Insights on Flights from Medellin to Santo Domingo

Which month has the cheapest one-way flights from to Santo Domingo?

Average monthly one-way flight prices from to Santo Domingo, based on bookings made by Trip.com users over the past 12 months.

Based on Trip.com’s data, the cheapest month for flights from to Santo Domingo is March, with an average price of US$178; while the month with the highest flight price is usually October, with an average price of up to US$248.

US$248
US$213
US$178
US$143
    Cheapest
  • US$230
    May
  • US$203
    Jun
  • US$222
    Jul
  • US$222
    Aug
  • US$194
    Sep
  • US$248
    Oct
  • US$227
    Nov
  • US$212
    Dec
  • US$227
    Jan
  • US$185
    Feb
  • US$178
    Mar
  • US$196
    Apr

Which month has the cheapest round-trip flights from to Santo Domingo?

The average price of round-trip flights from to Santo Domingo purchased by Trip.com users by month over the past 12 months.

Based on data from Trip.com, the lowest prices for round-trip flights from to Santo Domingo are found during October, with an average price of US$311. Conversely, the highest prices are found during May, with an average price of up to US$559.

US$559
US$435
US$311
US$187
    Cheapest
  • US$559
    May
  • US$348
    Jun
  • US$555
    Jul
  • US$320
    Aug
  • US$324
    Sep
  • US$311
    Oct
  • US$377
    Nov
  • US$386
    Dec
  • US$359
    Jan
  • US$325
    Feb
  • US$316
    Mar
  • US$340
    Apr

Frequently Asked Questions

  • What are the cheapest flights from Medellin to Santo Domingo (MDE-SDQ)?

    Based on Trip.com data, DM Airlines offers one-way fares as low as US$134 on Cheapest nonstop routes (e.g. MDE to SDQ on Wed, Jun 3), while DM Airlines offers Cheapest nonstop round-trips from US$247 departing on Sat, May 23 and returning on Wed, May 27.
  • At the moment, you can catch a nonstop flight from Medellin to Santo Domingo with the following airlines, including: Arajet Airline Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • It takes about 2 hours 32 minutes to fly from Medellin to Santo Domingo.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Medellin to Santo Domingo is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 7 flight per week flying from Medellin to Santo Domingo. You can check the weekly schedule for popular airlines on this route below: Arajet Airline: -/M/-/W/T/F/S -- DM1737 (10:22) Arajet Airline: -/M/T/-/T/-/- -- DM1739 (20:44)
  • To find best deals on flights from Medellin to Santo Domingo, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Jun 3, with one-way flights priced at just US$134.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is DM Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Santo Domingo travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Medellin to Santo Domingo is October, when demand for travel is lower.
  • After crunching the numbers on our May flight calendar, it's currently cheapest to fly from Medellin to Santo Domingo on May 22, 2026 with Arajet Airline, with prices starting at US$139.
  • You can land at any one of the following hubs in Santo Domingo, with Jose Maria Cordova International Airport to Las Américas International Airport (MDE-SDQ) is by far the most common option on this route: La Isabela International Airport (JBQ) Las Américas International Airport (SDQ).
  • The time difference between Santo Domingo and Medellin is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

Book with no extra fees

Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.