Cheapest airlines flights from Mexico City to Panama City

You can pick from 3 carriers that fly from Mexico City to Panama City including Aeromexico, avianca, Copa Airlines, with Aeromexico serving cheapest ticket on this route.
Airlines are determined based on actual purchased flight tickets from Mexico City to Panama City according to previous 12 months data from Trip.com.

Search for direct flights from Mexico City to Panama City in the next 3 months. Based on Trip.com's latest 7-day flight data, one-way direct flights start at US$127, and round-trip direct flights start at US$201.

Displayed flight fares from Mexico City to Panama City are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Mexico City to Panama City Flight Details

The distance between Mexico City and Panama City is about 2,403.84 km. The average flying time from Mexico City to Panama City is around 3 hours 44 minutes. Based on Trip.com's latest data, travel demand is highest in July. The off-season for travel is December.

Cheapest one-way flight priceUS$127
Cheapest return ticket priceUS$201
Cheapest monthDecember
Peak season for travelJuly
Flight distance2,403.84 km
Average flight time3 hours 44 minutes
Popular airlineAeromexico
Flight statistics for the Mexico City–Panama City route are based on aggregated booking data from Trip.com over the past 12 months.

When is the cheapest time to book flights from Mexico City to Panama City?

The cheapest time to fly from Mexico City to Panama City: Dec 28 to Jan 4 — one-way prices start at US$127.

Cheapest flights
From price
Search
  • 1421
  • 2128
  • Jan

    284
  • 411
  • 1118
  • 1825
  • Feb

    251
  • 18
  • 815
  • 1522
  • Mar

    221
  • 18
Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • What are the cheapest flights from Mexico City to Panama City (MEX-PTY)?

    Based on Trip.com data, Aeromexico offers one-way fares as low as US$127 on Cheapest nonstop routes (e.g. MEX to PTY on Thu, Jan 1), while Copa Airlines offers Cheapest nonstop round-trips from US$201 departing on Sat, Jan 24 and returning on Sat, Jan 31.
  • At the moment, you can catch a nonstop flight from Mexico City to Panama City with the following airlines, including: Aeromexico Copa Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • It takes about 3 hours 44 minutes to fly from Mexico City to Panama City.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Mexico City to Panama City is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 46 flight per week flying from Mexico City to Panama City. You can check the weekly schedule for popular airlines on this route below: Copa Airlines: S/M/T/W/T/F/S -- CM137 (09:45) Copa Airlines: S/M/T/W/T/F/S -- CM195 (06:26) Aeromexico: S/M/T/W/T/F/S -- AM464 (09:26)
  • To find best deals on flights from Mexico City to Panama City, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Thu, Jan 1, with one-way flights priced at just US$127.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Aeromexico.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Panama City travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Mexico City to Panama City is December, when demand for travel is lower.
  • After crunching the numbers on our December flight calendar, it's currently cheapest to fly from Mexico City to Panama City on December 31, 2025 with Aeromexico, with prices starting at US$241.
  • You can land at any one of the following hubs in Panama City, with Mexico City International Airport to Tocumen International Airport (MEX-PTY) is by far the most common option on this route: Albrook "Marcos A. Gelabert" International Airport (PAC) Tocumen International Airport (PTY).
  • The time difference between Panama City and Mexico City is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.