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Find cheap one-way flights from Mexico City to Santiago starting at US$207.

Book one-way or return flights from Mexico City to Santiago from as little as US$207. Choose from the popular airlines below and book your flight today!

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from Mexico City to Santiago?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Cheapest airlines flights from Mexico City to Santiago

Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

DM Airlines
From US$207
Avianca
From US$207
Copa Airlines
From US$209
Volaris
From US$251
Aeromexico
From US$275
LATAM Airlines
From US$276
Viva Aerobus
From US$319
Volaris Costa Rica
From US$332
Euroairlines
From US$455
American Airlines
From US$526
ANA airlines

Find more flights and airlines

Find cheap flights from Mexico City to Santiago by different airports

Searching for potential routes that might be cheaper and faster? Check out these alternative flights from Mexico City to Santiago.

  • Cheapest
    DM Airlines
    NLU
    09:25
    14h 35m
    1 transfer
    SCL
    03:00
    Felipe Ángeles International Airport - Arturo Merino Benitez Airport
    Thu, Mar 21DM Airlines
    US$207
  • Avianca
    MEX
    23:20
    12h 5m
    1 transfer
    SCL
    13:25
    Mexico City International Airport - Arturo Merino Benitez Airport
    Thu, Apr 11Avianca
    US$207
  • Volaris
    TLC
    09:28
    16h 42m
    2 transfer
    SCL
    04:10
    Toluca Airport - Arturo Merino Benitez Airport
    Sun, May 5Volaris
    US$251
  • Volaris
    TLC
    09:28
    16h 42m
    2 transfer
    SCL
    04:10
    Toluca Airport - Arturo Merino Benitez Airport
    Sun, May 5Volaris
    US$251
    Find More Flights

Frequently Asked Questions

  • When are flight tickets from Mexico City (MEX) to Santiago (SCL) the cheapest?

    Airlines adjust prices for flights from Mexico City to Santiago based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much do flights from Mexico City (MEX) to Santiago (SCL) cost?

    According to Trip.com's data, the lowest price is around $866.
  • How long does it take to fly from Mexico City (MEX) to Santiago (SCL) and what is the distance?

    It takes around 8 hours 30 minutes to fly from Mexico City (MEX) to Santiago (SCL).
  • What is the transportation method from the main airport to downtown in Santiago?

    • The distance from Arturo Merino Benitez Airport to downtown is about 13km. It takes about 30 minutes by taxi.
  • What are the most popular airlines that fly from Mexico City (MEX) to Santiago (SCL)?

    Airlines with flights from Mexico City (MEX) to Santiago (SCL): LATAM Airlines, Aeromexico and WestJet.

Mexico City to Santiago Flight Information

Cheapest nonstop flight price

$206

Cheapest round-trip ticket price

$481

Off-season for travel

March

Peak season for travel

September