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Find cheap one-way flights from Mexico City to Santo Domingo starting at US$110.

Book one-way or return flights from Mexico City to Santo Domingo from as little as US$110. Choose from the popular airlines below and book your flight today!

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from Mexico City to Santo Domingo?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Cheapest airlines flights from Mexico City to Santo Domingo

Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

DM Airlines
From US$110
Copa Airlines
From US$152
Aeromexico
From US$170
Volaris
From US$178
Avianca
From US$191
FlexFlight
From US$218
Euroairlines
From US$259
Delta Air Lines
From US$348
Volaris Costa Rica
From US$356
United Airlines
From US$372
ANA airlines

Find more flights and airlines

Find cheap flights from Mexico City to Santo Domingo by different airports

Searching for potential routes that might be cheaper and faster? Check out these alternative flights from Mexico City to Santo Domingo.

  • Cheapest
    DM Airlines
    NLU
    16:55
    4h 25m
    Direct
    SDQ
    23:20
    Felipe Ángeles International Airport - Las Américas International Airport
    Wed, Apr 3DM Airlines
    US$110
  • Aeromexico
    MEX
    00:15
    4h 27m
    Direct
    SDQ
    06:42
    Mexico City International Airport - Las Américas International Airport
    Thu, Apr 4Aeromexico
    US$170
  • Volaris
    TLC
    09:28
    28h 20m
    1 transfer
    SDQ
    15:48
    Toluca Airport - Las Américas International Airport
    Wed, Apr 3Volaris
    US$178
  • Volaris
    TLC
    09:28
    28h 20m
    1 transfer
    SDQ
    15:48
    Toluca Airport - Las Américas International Airport
    Wed, Apr 3Volaris
    US$178
    Find More Flights

Frequently Asked Questions

  • When are flight tickets from Mexico City (MEX) to Santo Domingo (SDQ) the cheapest?

    Airlines adjust prices for flights from Mexico City to Santo Domingo based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much do flights from Mexico City (MEX) to Santo Domingo (SDQ) cost?

    According to Trip.com's data, the lowest price is around $601.
  • How long does it take to fly from Mexico City (MEX) to Santo Domingo (SDQ) and what is the distance?

    It takes around 4 hours 25 minutes to fly from Mexico City (MEX) to Santo Domingo (SDQ).
  • What is the transportation method from the main airport to downtown in Santo Domingo?

    • The distance from Las Américas International Airport to downtown is about 33km. It takes about 50 minutes by taxi.
    • The distance from La Isabela International Airport to downtown is about 8km. It takes about 20 minutes by taxi.
  • What are the most popular airlines that fly from Mexico City (MEX) to Santo Domingo (SDQ)?

    Airlines with flights from Mexico City (MEX) to Santo Domingo (SDQ): Euroairlines, Hahn Air, FlexFlight, DM Airlines and Aeromexico.

Mexico City to Santo Domingo Flight Information

Cheapest nonstop flight price

$109

Cheapest round-trip ticket price

$237

Off-season for travel

February

Peak season for travel

September