Cheap Flights from Panama City to Madrid from US$571

Frequently Asked Questions

• What are the cheapest flights from Panama City to Madrid (PTY-MAD)?

  Based on Trip.com data, avianca offers one-way fares as low as US$571 on Cheapest nonstop routes (e.g. PTY to MAD on Thu, Jul 23), while United Airlines offers Cheapest nonstop round-trips from US$734 departing on Wed, Jul 15 and returning on Wed, Jul 22.

• Which airlines offer direct flights from Panama City to Madrid?

  At the moment, you can catch a nonstop flight from Panama City to Madrid with the following airlines, including: Air Europa Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.

• How long is a flight from Panama City to Madrid?

  It takes about 9 hours 56 minutes to fly from Panama City to Madrid.

• When is the best time to book flights from Panama City to Madrid?

  By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Panama City to Madrid is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

• How many flights are there per week from Panama City to Madrid?

  Based on Trip.com data in the past 4 weeks, there is 8 flight per week flying from Panama City to Madrid. You can check the weekly schedule for popular airlines on this route below: Copa Airlines: S/M/T/W/T/F/S -- CM8106 (20:35)

• How can I find the best deals on flights from Panama City to Madrid?

  To find best deals on flights from Panama City to Madrid, you can use various tools on Trip.com:
  · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Thu, Jul 23, with one-way flights priced at just US$571.
  · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Air Europa.
  · Set up price alerts to easily monitor ticket prices without having to check every day.
  · Check Trip.com flight deals and promo codes frequently.
  · Avoid peak season unless you book very early. It seems the peak season for Madrid travel is around January.
  · Get exclusive promo codes for Trip.com app users.

• When are flight tickets from Panama City (PTY) to Madrid (MAD) the cheapest?

  The cheapest months to fly from Panama City to Madrid is August, when demand for travel is lower.

• Which upcoming date is cheapest to fly from Panama City to Madrid on?

  After crunching the numbers on our June flight calendar, it's currently cheapest to fly from Panama City to Madrid on June 28, 2026 with avianca, with prices starting at US$354.

• Which airports can I fly to for Madrid from Panama City?

  You can land at any one of the following hubs in Madrid, with Tocumen International Airport to Madrid Barajas Airport (PTY-MAD) is by far the most common option on this route: Madrid Barajas Airport (MAD).

• Is there any time difference between Panama City and Madrid?

  The time difference between Madrid and Panama City is 6h.

• How do I change or cancel my ticket from Panama City to Madrid?

  Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.