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Flights from San Francisco to Lexington

Search cheap flights from San Francisco to Lexington in the next 3 months. Based on Trip.com's latest 7-day data, one-way fares start at US$237, and round-trip tickets start at US$330.

      • SFO 11:41
        7h 25m
        1 stop
        LEX 22:06
        San Francisco - Lexington | Wed, May 13 | Delta Air Lines
        LEX 10:43
        10h 6m
        1 stop
        SFO 17:49
        Lexington - San Francisco | Wed, May 20 | Delta Air Lines
        US$330 US$414
        20% off
        20% off
        US$414 US$330
      • SFO 05:50
        8h 22m
        1 stop
        LEX 17:12
        San Francisco - Lexington | Wed, May 27 | Delta Air Lines
        LEX 18:11
        8h 13m
        1 stop
        SFO 23:24
        Lexington - San Francisco | Wed, Jun 3 | Delta Air Lines
        US$330 US$414
        20% off
        20% off
        US$414 US$330
      • SFO 13:17
        7h 44m
        1 stop
        LEX 00:01
        San Francisco - Lexington | Wed, May 27 | American Airlines
        LEX 16:35
        9h 14m
        1 stop
        SFO 22:49
        Lexington - San Francisco | Wed, Jun 3 | American Airlines
        US$330 US$414
        20% off
        20% off
        US$414 US$330
      • SFO 22:59
        7h 17m
        1 stop
        LEX 09:16
        San Francisco - Lexington | Tue, Jul 7 | Delta Air Lines
        LEX 10:11
        10h 20m
        1 stop
        SFO 17:31
        Lexington - San Francisco | Tue, Jul 14 | Delta Air Lines
        US$330
        20% off
        US$414 US$330
      • SFO 05:40
        8h 41m
        1 stop
        LEX 17:21
        San Francisco - Lexington | Wed, Jul 8 | Delta Air Lines
        LEX 13:02
        10h 3m
        1 stop
        SFO 20:05
        Lexington - San Francisco | Wed, Jul 15 | Delta Air Lines
        US$330
        20% off
        US$414 US$330
      • SFO 23:55
        9h 24m
        1 stop
        LEX 12:19
        San Francisco - Lexington | Tue, Jun 2 | Delta Air Lines
        LEX 18:11
        7h 37m
        1 stop
        SFO 22:48
        Lexington - San Francisco | Sat, Jun 6 | Delta Air Lines
        US$336
        19% off
        US$414 US$336
      • SFO 22:55
        7h 26m
        1 stop
        LEX 09:21
        San Francisco - Lexington | Mon, Jun 1 | Delta Air Lines
        LEX 13:05
        9h
        1 stop
        SFO 19:05
        Lexington - San Francisco | Sat, Jun 6 | Delta Air Lines
        US$357
        14% off
        US$414 US$357
      • SFO 05:40
        8h 44m
        1 stop
        LEX 17:24
        San Francisco - Lexington | Tue, Jun 9 | Delta Air Lines
        LEX 19:59
        7h 46m
        1 stop
        SFO 00:45
        Lexington - San Francisco | Mon, Jun 15 | Delta Air Lines
        US$359
        13% off
        US$414 US$359
      • SFO 21:52
        7h 58m
        1 stop
        LEX 08:50
        San Francisco - Lexington | Thu, May 28 | American Airlines
        LEX 20:07
        7h 41m
        1 stop
        SFO 00:48
        Lexington - San Francisco | Mon, Jun 1 | American Airlines
        US$362
        13% off
        US$414 US$362
      • SFO 00:30
        9h 11m
        1 stop
        LEX 12:41
        San Francisco - Lexington | Wed, May 13 | American Airlines
        LEX 07:00
        8h 38m
        1 stop
        SFO 12:38
        Lexington - San Francisco | Wed, May 20 | American Airlines
        US$385
        7% off
        US$414 US$385
      • SFO 13:00
        17h 25m
        1 stop
        LEX 14:00
        San Francisco - Lexington | Thu, May 14 | Normal Airline
        LEX 15:00
        6h
        Nonstop
        SFO 16:00
        Lexington - San Francisco | Sat, May 16 | Normal Airline
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      • SFO 07:04
        11h 25m
        1 stop
        LEX 21:29
        San Francisco - Lexington | Thu, May 14 | Alaska Airlines
        US$237 US$309
        23% off
        23% off
        US$309 US$237
      • SFO 22:55
        7h 26m
        1 stop
        LEX 09:21
        San Francisco - Lexington | Fri, May 22 | Delta Air Lines
        US$278 US$309
        10% off
        10% off
        US$309 US$278
      • SFO 13:45
        7h 14m
        1 stop
        LEX 23:59
        San Francisco - Lexington | Sat, May 23 | Delta Air Lines
        US$278 US$309
        10% off
        10% off
        US$309 US$278
      • SFO 05:50
        8h 22m
        1 stop
        LEX 17:12
        San Francisco - Lexington | Sun, May 24 | Delta Air Lines
        US$278
        10% off
        US$309 US$278
      • SFO 06:00
        8h 11m
        1 stop
        LEX 17:11
        San Francisco - Lexington | Fri, Jun 12 | Delta Air Lines
        US$278
        10% off
        US$309 US$278
      • SFO 23:59
        7h 3m
        1 stop
        LEX 10:02
        San Francisco - Lexington | Thu, May 28 | Delta Air Lines
        US$285
        8% off
        US$309 US$285
      • SFO 21:56
        8h 29m
        1 stop
        LEX 09:25
        San Francisco - Lexington | Fri, Jun 26 | Delta Air Lines
        US$286
        7% off
        US$309 US$286
      • SFO 21:55
        8h 26m
        1 stop
        LEX 09:21
        San Francisco - Lexington | Fri, May 29 | Delta Air Lines
        US$287
        7% off
        US$309 US$287
      • SFO 13:00
        17h 25m
        1 stop
        LEX 14:00
        San Francisco - Lexington | Thu, May 14 | Normal Airline
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Displayed flight fares from San Francisco to Lexington are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Frequently Asked Questions

  • What are the cheapest flights from San Francisco to Lexington (SFO-LEX)?

    Based on Trip.com data, Alaska Airlines offers one-way fares as low as US$237 on Cheapest nonstop routes (e.g. SFO to LEX on Thu, May 14), while Delta Air Lines offers Cheapest nonstop round-trips from US$330 departing on Wed, May 13 and returning on Wed, May 20.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from San Francisco to Lexington is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from San Francisco to Lexington, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Thu, May 14, with one-way flights priced at just US$237.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Alaska Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Lexington travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from San Francisco to Lexington is October, when demand for travel is lower.
  • After crunching the numbers on our May flight calendar, it's currently cheapest to fly from San Francisco to Lexington on May 27, 2026 with American Airlines, with prices starting at US$330.
  • The time difference between Lexington and San Francisco is 3h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

Book with no extra fees

Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.