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Flights from Santa Ana to St. Louis

What to know about flights from Santa Ana to St. Louis?

The approximate distance between Santa Ana and St. Louis is 2,535.57 km. According to Trip.com data, travel demand hits its peak in July.

Cheapest one-way
US$165
American Airlines American Airlines SNA-STL 6h 38m · 1 stop Fri, Nov 20
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Cheapest round-trip
US$338
Delta Air Lines Delta Air Lines SNA-STL 8h 26m · 2 stops Wed, Nov 18 - Thu, Nov 19
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Recommended airlines
American Airlines American Airlines Cheapest · From US$165 American Airlines American Airlines Most booked
When to fly
October
Cheapest
July
Peak season
Route details
2,535.57 km
Flight distance

Explore the cheapest one-way and round-trip flights from Santa Ana to St. Louis over the next 90 days, with one-way fares from US$165 and round-trip from US$338. Based on Trip.com's latest 7-day flight data.

      • SNA 07:15
        8h 26m
        1 stop
        STL 17:41
        Santa Ana - St. Louis | Wed, Nov 18 | Delta Air Lines
        STL 06:13
        8h 37m
        1 stop
        SNA 12:50
        St. Louis - Santa Ana | Thu, Nov 19 | Delta Air Lines
        US$338 US$540
        37% off
        37% off
        US$540 US$338
      • SNA 06:45
        5h 45m
        1 stop
        STL 14:30
        Santa Ana - St. Louis | Sat, Oct 24 | American Airlines
        STL 05:40
        6h 12m
        1 stop
        SNA 09:52
        St. Louis - Santa Ana | Sun, Oct 25 | American Airlines
        US$358 US$540
        34% off
        34% off
        US$540 US$358
      • SNA 15:30
        6h 49m
        1 stop
        STL 00:19
        Santa Ana - St. Louis | Fri, Oct 16 | American Airlines
        STL 14:31
        6h
        1 stop
        SNA 18:31
        St. Louis - Santa Ana | Mon, Oct 19 | American Airlines
        US$359 US$540
        34% off
        34% off
        US$540 US$359
      • SNA 12:59
        9h
        1 stop
        STL 23:59
        Santa Ana - St. Louis | Thu, Oct 29 | Alaska Airlines
        STL 06:00
        9h 46m
        1 stop
        SNA 13:46
        St. Louis - Santa Ana | Wed, Nov 4 | Alaska Airlines
        US$381
        28% off
        US$540 US$381
      • SNA 08:00
        6h 43m
        1 stop
        STL 16:43
        Santa Ana - St. Louis | Thu, Oct 29 | Delta Air Lines
        STL 17:00
        7h 5m
        1 stop
        SNA 22:05
        St. Louis - Santa Ana | Mon, Nov 2 | Delta Air Lines
        US$391
        28% off
        US$540 US$391
      • SNA 16:55
        5h 49m
        1 stop
        STL 00:44
        Santa Ana - St. Louis | Wed, Oct 28 | Delta Air Lines
        STL 17:00
        7h 5m
        1 stop
        SNA 22:05
        St. Louis - Santa Ana | Mon, Nov 2 | Delta Air Lines
        US$391
        28% off
        US$540 US$391
      • SNA 07:00
        8h 44m
        1 stop
        STL 17:44
        Santa Ana - St. Louis | Wed, Oct 21 | Delta Air Lines
        STL 14:22
        6h
        1 stop
        SNA 18:22
        St. Louis - Santa Ana | Tue, Oct 27 | Delta Air Lines
        US$392
        27% off
        US$540 US$392
      • SNA 11:40
        10h 19m
        1 stop
        STL 23:59
        Santa Ana - St. Louis | Wed, Nov 11 | American Airlines
        STL 05:01
        11h 32m
        1 stop
        SNA 14:33
        St. Louis - Santa Ana | Sat, Nov 14 | American Airlines
        US$396
        27% off
        US$540 US$396
      • SNA 06:45
        5h 45m
        1 stop
        STL 14:30
        Santa Ana - St. Louis | Thu, Oct 29 | American Airlines
        STL 14:54
        6h 16m
        1 stop
        SNA 19:10
        St. Louis - Santa Ana | Mon, Nov 2 | American Airlines
        US$399
        26% off
        US$540 US$399
      • SNA 12:01
        5h 47m
        1 stop
        STL 19:48
        Santa Ana - St. Louis | Wed, Oct 21 | American Airlines
        STL 08:03
        5h 42m
        1 stop
        SNA 11:45
        St. Louis - Santa Ana | Tue, Oct 27 | American Airlines
        US$399
        26% off
        US$540 US$399
      • SNA 13:00
        17h 25m
        1 stop
        STL 14:00
        Santa Ana - St. Louis | Fri, Oct 16 | Normal Airline
        STL 15:00
        6h
        Nonstop
        SNA 16:00
        St. Louis - Santa Ana | Sun, Oct 18 | Normal Airline
        More cheap flights
        More cheap flights
      • SNA 14:57
        6h 38m
        1 stop
        STL 23:35
        Santa Ana - St. Louis | Fri, Nov 20 | American Airlines
        US$165 US$290
        43% off
        43% off
        US$290 US$165
      • SNA 08:00
        6h 31m
        1 stop
        STL 16:31
        Santa Ana - St. Louis | Fri, Nov 20 | Delta Air Lines
        US$167 US$290
        42% off
        42% off
        US$290 US$167
      • SNA 18:51
        14h 28m
        1 stop
        STL 11:19
        Santa Ana - St. Louis | Mon, Nov 16 | Frontier Airlines
        US$199 US$290
        31% off
        31% off
        US$290 US$199
      • SNA 09:12
        6h 43m
        1 stop
        STL 17:55
        Santa Ana - St. Louis | Wed, Nov 4 | American Airlines
        US$200
        31% off
        US$290 US$200
      • SNA 09:12
        7h 4m
        1 stop
        STL 18:16
        Santa Ana - St. Louis | Thu, Nov 19 | American Airlines
        US$200
        31% off
        US$290 US$200
      • SNA 11:06
        6h 9m
        1 stop
        STL 19:15
        Santa Ana - St. Louis | Fri, Nov 6 | Frontier Airlines
        US$203
        30% off
        US$290 US$203
      • SNA 16:32
        5h 17m
        1 stop
        STL 23:49
        Santa Ana - St. Louis | Sat, Nov 28 | American Airlines
        US$206
        28% off
        US$290 US$206
      • SNA 13:25
        5h 44m
        1 stop
        STL 21:09
        Santa Ana - St. Louis | Wed, Nov 4 | Delta Air Lines
        US$207
        28% off
        US$290 US$207
      • SNA 07:15
        8h 26m
        1 stop
        STL 17:41
        Santa Ana - St. Louis | Thu, Nov 19 | Delta Air Lines
        US$207
        28% off
        US$290 US$207
      • SNA 06:50
        8h 7m
        1 stop
        STL 16:57
        Santa Ana - St. Louis | Fri, Nov 6 | United Airlines
        US$214
        26% off
        US$290 US$214
      • SNA 13:00
        17h 25m
        1 stop
        STL 14:00
        Santa Ana - St. Louis | Fri, Oct 16 | Normal Airline
        More cheap flights
        More cheap flights

Which airlines are the most popular for Santa Ana to St. Louis flights?

You can choose from 1 airlines that fly from Santa Ana to St. Louis, including American Airlines, American Airlines has lowest fares on this route.
American Airlines logo American Airlines
Airlines are determined based on actual purchased flight tickets from Santa Ana to St. Louis according to previous 12 months data from Trip.com.

Frequently Asked Questions

  • What are the cheapest flights from Santa Ana to St. Louis (SNA-STL)?

    Based on Trip.com data, American Airlines offers one-way fares as low as US$165 on Cheapest nonstop routes (e.g. SNA to STL on Fri, Nov 20), while Delta Air Lines offers Cheapest nonstop round-trips from US$338 departing on Wed, Nov 18 and returning on Thu, Nov 19.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Santa Ana to St. Louis is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Santa Ana to St. Louis, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Fri, Nov 20, with one-way flights priced at just US$165.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is American Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for St. Louis travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Santa Ana to St. Louis is October, when demand for travel is lower.
  • After crunching the numbers on our October flight calendar, it's currently cheapest to fly from Santa Ana to St. Louis on October 14, 2026 with Delta Air Lines, with prices starting at US$340.
  • The time difference between St. Louis and Santa Ana is 2h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.
  • Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from Santa Ana to St. Louis is US$373. Fares vary by travel date, airline and availability.
  • Based on Trip.com data for travel in the next 30 days, the average round-trip fare from Santa Ana to St. Louis is US$1,191. The final price depends on the outbound and return dates, airline and fare conditions.
  • Enter Santa Ana and St. Louis, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveler details and complete payment to receive your confirmation.

Trip.com Airline Insights on Flights from Santa Ana to St. Louis

Which airline offers the cheapest direct flights from Santa Ana to St. Louis?

Data is based on the average price of all nonstop flights from Santa Ana to St. Louis on Trip.com over the past 12 months.

Based on Trip.com’s data from the past 12 months, Frontier Airlines provides the lowest-priced direct flights from Santa Ana to St. Louis, with fares starting at US$85.

US$85
US$374
US$663
US$951
Frontier Airlines
US$85
Frontier Airlines
American Airlines
US$380
American Airlines
United Airlines
US$951
United Airlines

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Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

Book with no extra fees

Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.