Cheapest airlines flights from Santa Cruz to Mexico City

You can choose from 1 airlines that fly from Santa Cruz to Mexico City, including Copa Airlines, avianca has lowest fares on this route.
Copa Airlines logo Copa Airlines
Airlines are determined based on actual purchased flight tickets from Santa Cruz to Mexico City according to previous 12 months data from Trip.com.

Search cheap flights from Santa Cruz to Mexico City in the next 3 months. Based on Trip.com's latest 7-day data, one-way fares start at US$323, and round-trip tickets start at US$556.

Displayed flight fares from Santa Cruz to Mexico City are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Santa Cruz to Mexico City Flight Details

The distance between Santa Cruz and Mexico City is about 5,702.49 km. Based on Trip.com's latest data, travel demand is highest in January. The off-season for travel is September.

Cheapest one-way flight priceUS$323
Cheapest return ticket priceUS$556
Cheapest monthSeptember
Peak season for travelJanuary
Flight distance5,702.49 km
Popular airlineCopa Airlines
Flight statistics for the Santa Cruz–Mexico City route are based on aggregated booking data from Trip.com over the past 12 months.

Frequently Asked Questions

  • What are the cheapest flights from Santa Cruz to Mexico City (SRZ-MEX)?

    Based on Trip.com data, avianca offers one-way fares as low as US$323 on Cheapest nonstop routes (e.g. VVI to MEX on Fri, Apr 24), while avianca offers Cheapest nonstop round-trips from US$556 departing on Thu, May 28 and returning on Thu, Jun 4.
  • At the moment, several airlines serve connecting flights from Santa Cruz to Mexico City, including: Copa Airlines Selected airlines are based on historical data collected from flight bookings made by users on Trip.com within the last 90 days.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Santa Cruz to Mexico City is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Santa Cruz to Mexico City, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Fri, Apr 24, with one-way flights priced at just US$323.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is avianca.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Mexico City travel is around January.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Santa Cruz to Mexico City is September, when demand for travel is lower.
  • After crunching the numbers on our April flight calendar, it's currently cheapest to fly from Santa Cruz to Mexico City on April 24, 2026 with avianca, with prices starting at US$323.
  • You can land at any one of the following hubs in Mexico City, with Viru Viru International Airport to Mexico City International Airport (VVI-MEX) is by far the most common option on this route: Mexico City International Airport (MEX) Felipe Ángeles International Airport (NLU) Lic. Adolfo López Mateos International Airport (TLC).
  • The time difference between Mexico City and Santa Cruz is 2h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Trip.com Airline Insights on Flights from Santa Cruz to Mexico City

Which airline offers the cheapest direct flights from Santa Cruz to Mexico City?

Data is based on the average price of all nonstop flights from Santa Cruz to Mexico City on Trip.com over the past 12 months.

Based on Trip.com’s data from the past 12 months, avianca provides the lowest-priced direct flights from Santa Cruz to Mexico City, with fares starting at US$509.

US$362
US$509
US$657
US$805
US$952
avianca
US$509
avianca
Copa Airlines
US$635
Copa Airlines
LATAM Airlines
US$684
LATAM Airlines
Gol Linhas Aereas Inteligentes
US$952
Gol Linhas Aereas Inteligentes

Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

Book with no extra fees

Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.