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Find cheap one-way flights from Santiago to Guayaquil starting at US$151.

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from Santiago to Guayaquil?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Cheapest airlines flights from Santiago to Guayaquil

Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

LATAM Airlines
From US$151
JetSMART Airlines
From US$152
Avianca
From US$156
Sky Airline
From US$161
Copa Airlines
From US$173
ANA airlines

Find more flights and airlines

Find cheap flights from Santiago to Guayaquil by different airports

Searching for potential routes that might be cheaper and faster? Check out these alternative flights from Santiago to Guayaquil.

  • Cheapest
    LATAM Airlines
    SCL
    07:20
    7h 51m
    1 transfer
    GYE
    14:11
    Arturo Merino Benitez Airport - Jose Joaquin De Olmedo International Airport
    Thu, Apr 25LATAM Airlines
    US$151
  • LATAM Airlines
    SCL
    07:20
    7h 51m
    1 transfer
    GYE
    14:11
    Arturo Merino Benitez Airport - Jose Joaquin De Olmedo International Airport
    Thu, Apr 25LATAM Airlines
    US$151
    Find More Flights

Frequently Asked Questions

  • When are flight tickets from Santiago (SCL) to Guayaquil (GYE) the cheapest?

    Airlines adjust prices for flights from Santiago to Guayaquil based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much do flights from Santiago (SCL) to Guayaquil (GYE) cost?

    According to Trip.com's data, the lowest price is around $330.
  • How long does it take to fly from Santiago (SCL) to Guayaquil (GYE) and what is the distance?

    It takes around 5 hours 19 minutes to fly from Santiago (SCL) to Guayaquil (GYE).
  • What is the transportation method from the main airport to downtown in Guayaquil?

    • The distance from Jose Joaquin De Olmedo International Airport to downtown is about 4km. It takes about 20 minutes by taxi.
  • What are the most popular airlines that fly from Santiago (SCL) to Guayaquil (GYE)?

    Airlines with flights from Santiago (SCL) to Guayaquil (GYE): LATAM Airlines.

Santiago to Guayaquil Flight Information

Cheapest nonstop flight price

$150

Cheapest round-trip ticket price

$326

Off-season for travel

March

Peak season for travel

January