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Find cheap one-way flights from Santiago to Houston starting at US$224.

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from Santiago to Houston?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Cheapest airlines flights from Santiago to Houston

Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Spirit Airlines
From US$183
Jetblue Airways
From US$224
United Airlines
From US$371
Delta Air Lines
From US$502
American Airlines
From US$610
Silver Airways
From US$677
ANA airlines

Find more flights and airlines

Find cheap flights from Santiago to Houston by different airports

Searching for potential routes that might be cheaper and faster? Check out these alternative flights from Santiago to Houston.

  • Cheapest
    Spirit Airlines
    STI
    02:59
    32h 28m
    2 transfer
    IAH
    10:27
    Cibao International Airport - George Bush Intercontinental Airport
    Mon, Apr 1Spirit Airlines
    US$183
  • American Airlines
    STI
    16:58
    17h 41m
    2 transfer
    HOU
    09:39
    Cibao International Airport - William P. Hobby Airport
    Fri, Apr 19American Airlines
    US$610
  • American Airlines
    STI
    16:58
    17h 41m
    2 transfer
    HOU
    09:39
    Cibao International Airport - William P. Hobby Airport
    Fri, Apr 19American Airlines
    US$610
    Find More Flights

Frequently Asked Questions

  • When are flight tickets from Santiago (STI) to Houston (HOU) the cheapest?

    Airlines adjust prices for flights from Santiago to Houston based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much do flights from Santiago (STI) to Houston (HOU) cost?

    According to Trip.com's data, the lowest price is around $815.

Santiago to Houston Flight Information

Cheapest nonstop flight price

$224

Off-season for travel

January

Peak season for travel

June