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Flights from Santiago to Manaus

Search cheap flights from Santiago to Manaus in the next 3 months. Based on Trip.com's latest 7-day data, one-way fares start at US$194, and round-trip tickets start at US$479.

      • SCL 05:00
        10h 35m
        1 stop
        MAO 15:35
        Santiago - Manaus | Sun, Apr 19 | LATAM Airlines
        MAO 11:35
        11h 55m
        1 stop
        SCL 23:30
        Manaus - Santiago | Sun, Apr 26 | LATAM Airlines
        US$479 US$583
        18% off
        18% off
        US$583 US$479
      • SCL 20:45
        18h 50m
        1 stop
        MAO 15:35
        Santiago - Manaus | Fri, May 22 | LATAM Airlines
        MAO 18:20
        21h 5m
        1 stop
        SCL 15:25
        Manaus - Santiago | Thu, May 28 | LATAM Airlines
        US$493 US$583
        15% off
        15% off
        US$583 US$493
      • SCL 16:25
        10h 5m
        1 stop
        MAO 02:30
        Santiago - Manaus | Tue, Apr 14 | LATAM Airlines
        MAO 19:35
        14h 55m
        1 stop
        SCL 10:30
        Manaus - Santiago | Sun, Apr 19 | LATAM Airlines
        US$498 US$583
        15% off
        15% off
        US$583 US$498
      • SCL 06:40
        20h 25m
        1 stop
        MAO 03:05
        Santiago - Manaus | Wed, May 13 | avianca
        MAO 16:20
        19h
        1 stop
        SCL 11:20
        Manaus - Santiago | Wed, May 20 | LATAM Airlines
        US$511
        12% off
        US$583 US$511
      • SCL 07:20
        14h 25m
        1 stop
        MAO 21:45
        Santiago - Manaus | Tue, May 5 | LATAM Airlines
        MAO 11:35
        11h 50m
        1 stop
        SCL 23:25
        Manaus - Santiago | Wed, May 13 | LATAM Airlines
        US$513
        12% off
        US$583 US$513
      • SCL 06:40
        20h 25m
        1 stop
        MAO 03:05
        Santiago - Manaus | Fri, May 22 | avianca
        MAO 04:10
        24h 35m
        1 stop
        SCL 04:45
        Manaus - Santiago | Thu, May 28 | avianca
        US$515
        12% off
        US$583 US$515
      • SCL 16:25
        18h 35m
        1 stop
        MAO 11:00
        Santiago - Manaus | Thu, May 21 | LATAM Airlines
        MAO 04:10
        19h 10m
        1 stop
        SCL 23:20
        Manaus - Santiago | Thu, May 28 | avianca
        US$518
        11% off
        US$583 US$518
      • SCL 05:00
        16h 45m
        1 stop
        MAO 21:45
        Santiago - Manaus | Wed, May 13 | LATAM Airlines
        MAO 18:20
        17h
        1 stop
        SCL 11:20
        Manaus - Santiago | Wed, May 20 | LATAM Airlines
        US$523
        10% off
        US$583 US$523
      • SCL 15:20
        11h 45m
        1 stop
        MAO 03:05
        Santiago - Manaus | Sun, Apr 19 | avianca
        MAO 16:20
        18h 10m
        1 stop
        SCL 10:30
        Manaus - Santiago | Sun, Apr 26 | LATAM Airlines
        US$527
        10% off
        US$583 US$527
      • SCL 16:25
        10h
        1 stop
        MAO 02:25
        Santiago - Manaus | Mon, May 4 | LATAM Airlines
        MAO 16:45
        18h 35m
        1 stop
        SCL 11:20
        Manaus - Santiago | Mon, May 11 | LATAM Airlines
        US$536
        8% off
        US$583 US$536
      • SCL 13:00
        17h 25m
        1 stop
        MAO Invalid Date
        Santiago - Manaus | Sun, Apr 12 | Normal Airline
        MAO 15:00
        6h
        Nonstop
        SCL 16:00
        Manaus - Santiago | Tue, Apr 14 | Normal Airline
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      • SCL 05:00
        16h 45m
        1 stop
        MAO 21:45
        Santiago - Manaus | Tue, May 5 | LATAM Airlines
        US$194 US$273
        28% off
        28% off
        US$273 US$194
      • SCL 05:00
        16h 35m
        1 stop
        MAO 21:35
        Santiago - Manaus | Tue, Apr 14 | LATAM Airlines
        US$210 US$273
        23% off
        23% off
        US$273 US$210
      • SCL 05:00
        29h 50m
        1 stop
        MAO 10:50
        Santiago - Manaus | Sat, Apr 25 | LATAM Airlines
        US$221 US$273
        19% off
        19% off
        US$273 US$221
      • SCL 05:00
        10h 35m
        1 stop
        MAO 15:35
        Santiago - Manaus | Fri, Apr 24 | LATAM Airlines
        US$221
        19% off
        US$273 US$221
      • SCL 06:10
        20h 50m
        1 stop
        MAO 03:00
        Santiago - Manaus | Fri, Apr 24 | avianca
        US$244
        11% off
        US$273 US$244
      • SCL 06:10
        20h 50m
        1 stop
        MAO 03:00
        Santiago - Manaus | Sat, Apr 25 | avianca
        US$244
        11% off
        US$273 US$244
      • SCL 20:45
        18h 50m
        1 stop
        MAO 15:35
        Santiago - Manaus | Thu, Apr 30 | LATAM Airlines
        US$248
        9% off
        US$273 US$248
      • SCL 15:55
        10h 35m
        1 stop
        MAO 02:30
        Santiago - Manaus | Wed, Apr 29 | LATAM Airlines
        US$249
        9% off
        US$273 US$249
      • SCL 19:00
        15h 45m
        1 stop
        MAO 10:45
        Santiago - Manaus | Tue, May 12 | LATAM Airlines
        US$251
        8% off
        US$273 US$251
      • SCL 13:40
        9h 40m
        1 stop
        MAO 23:20
        Santiago - Manaus | Thu, May 14 | LATAM Airlines
        US$251
        8% off
        US$273 US$251
      • SCL 13:00
        17h 25m
        1 stop
        MAO Invalid Date
        Santiago - Manaus | Sun, Apr 12 | Normal Airline
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        Find more flights

Displayed flight fares from Santiago to Manaus are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Santiago to Manaus Flight Details

The distance between Santiago and Manaus is about 3,553.7 km. Based on Trip.com's latest data, travel demand is highest in January. The off-season for travel is September.

Cheapest one-way flight priceUS$194
Cheapest return ticket priceUS$479
Cheapest monthSeptember
Peak season for travelJanuary
Flight distance3,553.7 km
Flight statistics for the Santiago–Manaus route are based on aggregated booking data from Trip.com over the past 12 months.

Frequently Asked Questions

  • What are the cheapest flights from Santiago to Manaus (SCL-MAO)?

    Based on Trip.com data, LATAM Airlines offers one-way fares as low as US$194 on Cheapest nonstop routes (e.g. SCL to MAO on Tue, May 5), while LATAM Airlines offers Cheapest nonstop round-trips from US$479 departing on Sun, Apr 19 and returning on Sun, Apr 26.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Santiago to Manaus is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from Santiago to Manaus, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Tue, May 5, with one-way flights priced at just US$194.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is LATAM Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Manaus travel is around January.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Santiago to Manaus is September, when demand for travel is lower.
  • After crunching the numbers on our April flight calendar, it's currently cheapest to fly from Santiago to Manaus on April 19, 2026 with LATAM Airlines, with prices starting at US$479.
  • The time difference between Manaus and Santiago is 0h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

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Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.