Cheapest airlines flights from Santo Domingo to Medellin

You can choose from 2 airlines that fly from Santo Domingo to Medellin, including DM Airlines, Copa Airlines, DM Airlines has lowest fares on this route.
DM Airlines logo DM Airlines
Copa Airlines logo Copa Airlines
Airlines are determined based on actual purchased flight tickets from Santo Domingo to Medellin according to previous 12 months data from Trip.com.

Search for direct flights from Santo Domingo to Medellin in the next 3 months. Based on Trip.com's latest 7-day flight data, one-way direct flights start at US$95, and round-trip direct flights start at US$232.

Displayed flight fares from Santo Domingo to Medellin are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Santo Domingo to Medellin Flight Details

The distance between Santo Domingo and Medellin is about 1,493.25 km. The average flying time from Santo Domingo to Medellin is around 2 hours 36 minutes. Based on Trip.com's latest data, travel demand is highest in July. The off-season for travel is October.

Cheapest one-way flight priceUS$95
Cheapest return ticket priceUS$232
Cheapest monthOctober
Peak season for travelJuly
Flight distance1,493.25 km
Average flight time2 hours 36 minutes
Popular airlineArajet Airline
Flight statistics for the Santo Domingo–Medellin route are based on aggregated booking data from Trip.com over the past 12 months.

Trip.com Price Insights on Flights from Santo Domingo to Medellin

Which month has the cheapest one-way flights from Santo Domingo to Medellin?

The average price of one-way flights from Santo Domingo to Medellin purchased by Trip.com users by month over the past 12 months.

Based on Trip.com’s data, the cheapest month for flights from Santo Domingo to Medellin is April, with an average price of US$119; while the month with the highest flight price is usually June, with an average price of up to US$273.

US$273
US$196
US$119
US$42
  • US$119
    Apr
  • US$265
    May
  • US$273
    Jun
  • US$257
    Jul
  • US$191
    Aug
  • US$185
    Sep
  • US$168
    Oct
  • US$231
    Nov
  • US$239
    Dec
  • US$182
    Jan
  • US$161
    Feb
  • US$159
    Mar

What is the cheapest day of the week to fly from Santo Domingo to Medellin?

Average weekly flight prices from Santo Domingo to Medellin by travel date (Based on Trip.com’s past 12 months of data)

Based on Trip.com’s past 12 months of flight data, the cheapest day to fly from Santo Domingo to Medellin is Tuesday, with average prices lower than on other days. Avoid Thursday, as prices are usually highest then.

US$253
US$213
US$172
US$132
  • US$222
    Mon
  • US$172
    Tue
  • US$180
    Wed
  • US$253
    Thu
  • US$192
    Fri
  • US$191
    Sat
  • US$174
    Sun

When is the cheapest day to fly from Santo Domingo to Medellin during International Workers' Day?

Based on Trip.com's data over the past 3 days, these are the lowest one-way flight prices from Santo Domingo to Medellin during International Workers' Day.

International Workers' Day is scheduled for May 1. The cheapest flights from Santo Domingo to Medellin are available on May 3, with fares starting at US$129.

US$181
US$155
US$129
US$103
    Cheapest
  • US$138
    27
    Apr
  • US$141
    28
  • US$151
    29
  • US$181
    30
  • US$152
    1
    May
  • US$148
    2
  • US$129
    3

Frequently Asked Questions

  • What are the cheapest flights from Santo Domingo to Medellin (SDQ-MDE)?

    Based on Trip.com data, DM Airlines offers one-way fares as low as US$95 on Cheapest nonstop routes (e.g. SDQ to MDE on Wed, May 27), while DM Airlines offers Cheapest nonstop round-trips from US$232 departing on Tue, Jun 9 and returning on Sat, Jun 13.
  • At the moment, you can catch a nonstop flight from Santo Domingo to Medellin with the following airlines, including: Arajet Airline Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • It takes about 2 hours 36 minutes to fly from Santo Domingo to Medellin.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Santo Domingo to Medellin is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 7 flight per week flying from Santo Domingo to Medellin. You can check the weekly schedule for popular airlines on this route below: Arajet Airline: -/M/-/W/T/F/S -- DM1736 (08:32) Arajet Airline: -/M/T/-/T/-/- -- DM1738 (14:26)
  • To find best deals on flights from Santo Domingo to Medellin, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, May 27, with one-way flights priced at just US$95.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is DM Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Medellin travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Santo Domingo to Medellin is October, when demand for travel is lower.
  • After crunching the numbers on our April flight calendar, it's currently cheapest to fly from Santo Domingo to Medellin on April 21, 2026 with Arajet Airline, with prices starting at US$102.
  • You can land at any one of the following hubs in Medellin, with Las Américas International Airport to Jose Maria Cordova International Airport (SDQ-MDE) is by far the most common option on this route: Olaya Herrera Airport (EOH) Jose Maria Cordova International Airport (MDE).
  • The time difference between Medellin and Santo Domingo is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Trip.com Airline Insights on Flights from Santo Domingo to Medellin

Which airline offers the cheapest direct flights from Santo Domingo to Medellin?

Data is based on the average price of all nonstop flights from Santo Domingo to Medellin on Trip.com over the past 12 months.

Based on Trip.com’s data from the past 12 months, DM Airlines provides the lowest-priced direct flights from Santo Domingo to Medellin, with fares starting at US$201.

US$156
US$201
US$246
US$291
US$336
DM Airlines
US$201
DM Airlines
Euroairlines
US$220
Euroairlines
Copa Airlines
US$266
Copa Airlines
avianca
US$336
avianca

Which airline operates the most flights from Santo Domingo to Medellin?

Total flights from Santo Domingo to Medellin across all airlines. (Based on Trip.com data from the past month)

Based on Trip.com’s data from the past month, DM Airlines operates the most frequent flights from Santo Domingo to Medellin, with 9 flights per week.

0
3
6
9
DM Airlines
9
DM Airlines
Euroairlines
4
Euroairlines
Aero Republica S.A.
3
Aero Republica S.A.

How many flights fly from Santo Domingo to Medellin daily?

The data is based on the flight numbers for each day of the week from Santo Domingo to Medellin within the Trip.com database over the past month.

Based on the past month's historical data from Trip.com, the number of flights from Santo Domingo to Medellin is the highest on Tuesday/Saturday and the lowest on Monday/Wednesday.

12
9
6
3
Highest
6
Mon
12
Tue
6
Wed
9
Thu
9
Fri
12
Sat
7
Sun

Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

Book with no extra fees

Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.