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Flights from St. Louis to Brussels

Search cheap flights from St. Louis to Brussels in the next 3 months. Based on Trip.com's latest 7-day data, one-way fares start at US$454, and round-trip tickets start at US$925.

      • STL 07:00
        17h 45m
        1 stop
        BRU 07:45
        St. Louis - Brussels | Wed, Aug 19 | United Airlines
        BRU 09:30
        16h 12m
        1 stop
        STL 18:42
        Brussels - St. Louis | Sun, Aug 23 | Air Canada
        US$925 US$1,049
        12% off
        12% off
        US$1,049 US$925
      • STL 07:00
        17h 45m
        1 stop
        BRU 07:45
        St. Louis - Brussels | Wed, Aug 26 | United Airlines
        BRU 11:10
        31h 12m
        1 stop
        STL 11:22
        Brussels - St. Louis | Wed, Sep 2 | United Airlines
        US$926 US$1,049
        12% off
        12% off
        US$1,049 US$926
      • STL 18:54
        31h 6m
        1 stop
        BRU 09:00
        St. Louis - Brussels | Thu, Aug 20 | United Airlines
        BRU 10:15
        12h 23m
        1 stop
        STL 15:38
        Brussels - St. Louis | Fri, Aug 28 | United Airlines
        US$926 US$1,049
        12% off
        12% off
        US$1,049 US$926
      • STL 12:10
        12h
        1 stop
        BRU 07:10
        St. Louis - Brussels | Wed, Aug 19 | Air Canada
        BRU 09:30
        16h 12m
        1 stop
        STL 18:42
        Brussels - St. Louis | Sun, Aug 23 | United Airlines
        US$928
        12% off
        US$1,049 US$928
      • STL 12:10
        12h
        1 stop
        BRU 07:10
        St. Louis - Brussels | Wed, Aug 26 | Air Canada
        BRU 09:30
        16h 12m
        1 stop
        STL 18:42
        Brussels - St. Louis | Wed, Sep 2 | Air Canada
        US$928
        12% off
        US$1,049 US$928
      • STL 10:51
        13h 49m
        1 stop
        BRU 07:40
        St. Louis - Brussels | Sat, Aug 1 | Air France
        BRU 09:45
        13h 32m
        1 stop
        STL 16:17
        Brussels - St. Louis | Sun, Aug 9 | KLM
        US$935
        11% off
        US$1,049 US$935
      • STL 10:51
        13h 49m
        1 stop
        BRU 07:40
        St. Louis - Brussels | Sat, Aug 1 | KLM
        BRU 09:45
        13h 32m
        1 stop
        STL 16:17
        Brussels - St. Louis | Sun, Aug 9 | KLM
        US$935
        11% off
        US$1,049 US$935
      • STL 18:58
        29h 42m
        1 stop
        BRU 07:40
        St. Louis - Brussels | Sat, Aug 1 | Delta Air Lines
        BRU 09:45
        13h 32m
        1 stop
        STL 16:17
        Brussels - St. Louis | Sun, Aug 9 | KLM
        US$941
        10% off
        US$1,049 US$941
      • STL 15:30
        13h 20m
        1 stop
        BRU 11:50
        St. Louis - Brussels | Wed, Aug 26 | Lufthansa
        BRU 11:10
        31h 12m
        1 stop
        STL 11:22
        Brussels - St. Louis | Wed, Sep 2 | United Airlines
        US$947
        10% off
        US$1,049 US$947
      • STL 07:00
        17h 45m
        1 stop
        BRU 07:45
        St. Louis - Brussels | Tue, Sep 8 | United Airlines
        BRU 09:55
        17h 5m
        1 stop
        STL 20:00
        Brussels - St. Louis | Sun, Sep 13 | Air Canada
        US$954
        9% off
        US$1,049 US$954
      • STL 13:00
        17h 25m
        1 stop
        BRU 14:00
        St. Louis - Brussels | Fri, Jul 17 | Normal Airline
        BRU 15:00
        6h
        Nonstop
        STL 16:00
        Brussels - St. Louis | Sun, Jul 19 | Normal Airline
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      • STL 12:10
        12h
        1 stop
        BRU 07:10
        St. Louis - Brussels | Mon, Aug 24 | Air Canada
        US$454 US$531
        15% off
        15% off
        US$531 US$454
      • STL 12:27
        12h 18m
        1 stop
        BRU 07:45
        St. Louis - Brussels | Mon, Aug 24 | United Airlines
        US$462 US$531
        13% off
        13% off
        US$531 US$462
      • STL 06:01
        18h 44m
        1 stop
        BRU 07:45
        St. Louis - Brussels | Mon, Aug 3 | United Airlines
        US$467 US$531
        12% off
        12% off
        US$531 US$467
      • STL 06:01
        18h 44m
        1 stop
        BRU 07:45
        St. Louis - Brussels | Mon, Jul 20 | United Airlines
        US$470
        11% off
        US$531 US$470
      • STL 06:00
        20h
        1 stop
        BRU 09:00
        St. Louis - Brussels | Fri, Aug 28 | United Airlines
        US$471
        11% off
        US$531 US$471
      • STL 06:00
        20h
        1 stop
        BRU 09:00
        St. Louis - Brussels | Sat, Aug 29 | United Airlines
        US$471
        11% off
        US$531 US$471
      • STL 12:27
        12h 18m
        1 stop
        BRU 07:45
        St. Louis - Brussels | Sun, Aug 30 | United Airlines
        US$473
        11% off
        US$531 US$473
      • STL 09:15
        15h 25m
        1 stop
        BRU 07:40
        St. Louis - Brussels | Mon, Aug 24 | Delta Air Lines
        US$483
        9% off
        US$531 US$483
      • STL 12:52
        11h 48m
        1 stop
        BRU 07:40
        St. Louis - Brussels | Mon, Aug 24 | Air France
        US$483
        9% off
        US$531 US$483
      • STL 11:00
        13h 40m
        1 stop
        BRU 07:40
        St. Louis - Brussels | Mon, Aug 24 | KLM
        US$483
        9% off
        US$531 US$483
      • STL 13:00
        17h 25m
        1 stop
        BRU 14:00
        St. Louis - Brussels | Fri, Jul 17 | Normal Airline
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        Find more flights

Cheapest airlines flights from St. Louis to Brussels

You can choose from 1 airlines that fly from St. Louis to Brussels, including Delta Air Lines, Air Canada has lowest fares on this route.
Delta Air Lines logo Delta Air Lines
Airlines are determined based on actual purchased flight tickets from St. Louis to Brussels according to previous 12 months data from Trip.com.

St. Louis to Brussels Flight Details

The distance between St. Louis and Brussels is about 7,074.62 km. Based on Trip.com's latest data, travel demand is highest in January. The off-season for travel is November.

Cheapest one-way flight priceUS$454
Cheapest return ticket priceUS$925
Cheapest monthNovember
Peak season for travelJanuary
Flight distance7,074.62 km
Popular airlineDelta Air Lines
Flight statistics for the St. Louis–Brussels route are based on aggregated booking data from Trip.com over the past 12 months.

Frequently Asked Questions

  • What are the cheapest flights from St. Louis to Brussels (STL-BRU)?

    Based on Trip.com data, Air Canada offers one-way fares as low as US$454 on Cheapest nonstop routes (e.g. STL to BRU on Mon, Aug 24), while United Airlines offers Cheapest nonstop round-trips from US$925 departing on Wed, Aug 19 and returning on Sun, Aug 23.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from St. Louis to Brussels is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • To find best deals on flights from St. Louis to Brussels, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Mon, Aug 24, with one-way flights priced at just US$454.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Air Canada.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Brussels travel is around January.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from St. Louis to Brussels is November, when demand for travel is lower.
  • After crunching the numbers on our July flight calendar, it's currently cheapest to fly from St. Louis to Brussels on July 29, 2026 with United Airlines, with prices starting at US$467.
  • The time difference between Brussels and St. Louis is 7h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

Book with no extra fees

Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.