Find Air Europa(UX) flights from Panama City to Madrid

At the moment, you can catch a nonstop flight from Panama City to Madrid with the following airlines, including: Air Europa Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.

It takes about 9 hours 57 minutes to fly from Panama City to Madrid.

By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Panama City to Madrid is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

Based on Trip.com data in the past 4 weeks, there is 10 flight per week flying from Panama City to Madrid. You can check the weekly schedule for popular airlines on this route below: Air Europa: S/M/T/W/T/F/S -- UX056 (20:44)

The cheapest months to fly from Panama City to Madrid is August, when demand for travel is lower.

After crunching the numbers on our October flight calendar, it's currently cheapest to fly from Panama City to Madrid on October 23, 2026 with Air Europa, with prices starting at US$524.

You can land at any one of the following hubs in Madrid: Madrid Barajas Airport (MAD). Flying from Tocumen International Airport to Madrid Barajas Airport (PTY-MAD) is by far the most common option on this route.

The time difference between Madrid and Panama City is 6h.

Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.