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Find cheap one-way flights from Knoxville to Mexico City starting at US$251.

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from Knoxville to Mexico City?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Cheapest airlines flights from Knoxville to Mexico City

Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Frontier Airlines
From US$251
Aeromexico
From US$284
United Airlines
From US$297
American Airlines
From US$358
Allegiant Air
From US$359
Delta Air Lines
From US$447
ANA airlines

Find more flights and airlines

Find cheap flights from Knoxville to Mexico City by different airports

Searching for potential routes that might be cheaper and faster? Check out these alternative flights from Knoxville to Mexico City.

  • Cheapest
    Frontier Airlines
    TYS
    10:58
    8h 32m
    1 transfer
    MEX
    17:30
    Mcghee Tyson Airport - Mexico City International Airport
    Sat, May 11Frontier Airlines
    US$251
  • Aeromexico
    TYS
    05:30
    20h 25m
    2 transfer
    TLC
    23:55
    Mcghee Tyson Airport - Toluca Airport
    Tue, May 7Aeromexico
    US$291
  • United Airlines
    TYS
    07:00
    6h 7m
    1 transfer
    NLU
    11:07
    Mcghee Tyson Airport - Felipe Ángeles International Airport
    Wed, Apr 10United Airlines
    US$297
  • United Airlines
    TYS
    07:00
    6h 7m
    1 transfer
    NLU
    11:07
    Mcghee Tyson Airport - Felipe Ángeles International Airport
    Wed, Apr 10United Airlines
    US$297
    Find More Flights

Frequently Asked Questions

  • When are flight tickets from Knoxville (TYS) to Mexico City (MEX) the cheapest?

    Airlines adjust prices for flights from Knoxville to Mexico City based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much do flights from Knoxville (TYS) to Mexico City (MEX) cost?

    According to Trip.com's data, the lowest price is around $586.
  • What is the transportation method from the main airport to downtown in Mexico City?

    • The distance from Mexico City International Airport to downtown is about 6km. It takes about 20 minutes by taxi.
    • The distance from Felipe Ángeles International Airport to downtown is about 35km. It takes about 50 minutes by taxi.
    • The distance from Toluca Airport to downtown is about 47km. It takes about 1 hour by taxi.

Knoxville to Mexico City Flight Information

Cheapest nonstop flight price

$250

Off-season for travel

March

Peak season for travel

December