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Find cheap one-way flights from Santo Domingo to Columbus starting at US$252.

We've found these cheap flights for you. You can book one-way or round-trip flight tickets.

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

When is the cheapest time to book flights from Santo Domingo to Columbus?

We monitor flight fares to help you find the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Cheapest airlines flights from Santo Domingo to Columbus

Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Copa Airlines
From US$248
Spirit Airlines
From US$252
Jetblue Airways
From US$258
Delta Air Lines
From US$308
United Airlines
From US$319
American Airlines
From US$388
Frontier Airlines
From US$420
Euroairlines
From US$538
ANA airlines

Find more flights and airlines

Find cheap flights from Santo Domingo to Columbus by different airports

Searching for potential routes that might be cheaper and faster? Check out these alternative flights from Santo Domingo to Columbus.

  • Cheapest
    Copa Airlines
    SDQ
    12:13
    28h 4m
    2 transfer
    CMH
    16:17
    Las Américas International Airport - John Glenn Columbus International Airport
    Tue, Apr 2Copa Airlines
    US$248
  • Spirit Airlines
    SDQ
    07:11
    13h 33m
    1 transfer
    LCK
    20:44
    Las Américas International Airport - Rickenbacker International Airport
    Mon, Apr 1Spirit Airlines
    US$436
  • Spirit Airlines
    SDQ
    07:11
    13h 33m
    1 transfer
    LCK
    20:44
    Las Américas International Airport - Rickenbacker International Airport
    Mon, Apr 1Spirit Airlines
    US$436
    Find More Flights

Frequently Asked Questions

  • When are flight tickets from Santo Domingo (SDQ) to Columbus (CMH) the cheapest?

    Airlines adjust prices for flights from Santo Domingo to Columbus based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much do flights from Santo Domingo (SDQ) to Columbus (CMH) cost?

    According to Trip.com's data, the lowest price is around $511.

Santo Domingo to Columbus Flight Information

Cheapest nonstop flight price

$251

Off-season for travel

December

Peak season for travel

September