The Best of Upstate Hotels Is in Historic Newberry, SC Welcome to the Holiday Inn Express? Hotel & Suites Newberry. As the premier choice among hotels in the Newberry, SC area, we are conveniently located at exit 76 off of I-26, about 30 minutes north of Columbia and less than an hour south of Greenville, SC. Business guests to Newberry, SC appreciate our hotel's close proximity to companies including Caterpillar, Komatsu, Kiswire, International Paper Co., Georgia Pacific and Louis Rich. We're just six miles from the Newberry County Memorial Hospital, as well. We're also pleased to provide a 24-hour Business Center and two spacious meeting rooms, which are suitable for up to 85 people. From the famous Newberry Opera House and the Newberry County Historical Museum to historic downtown and the Country Club of Newberry, SC, our hotel's guests have much to see and do. Newberry College is just minutes away, as well, making us the preferred choice for those on college visits in Newberry, SC. Our hotel's fantastic amenities, including an indoor pool, whirlpool and Fitness Center, make it easy for travelers to unwind. Be sure to stop by our complimentary Express Start Breakfast Bar each morning for delights like our signature cinnamon rolls and Smart Roast coffee. Few hotels in Newberry, SC can provide travelers with these perks backed by the reputable name they trust. 'Stay Smart' at the Holiday Inn Express? Hotel & Suites.