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Santa Cruz to Guayaquil - Flights Starting at US$254

Book one-way or return flights from Santa Cruz to Guayaquil from as little as US$254. Choose from the popular airlines below and book your flight today!

  • One way
  • Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

We've found these cheap flights for you. You may book a one-way or round trip as per your needs.

We monitor flight fares to help you seize the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.
Cheapest airlines flights from Santa Cruz to Guayaquil

View airlines operating flights from Santa Cruz to Guayaquil. Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Avianca
From US$254
Boliviana De Aviación
From US$275
LATAM Airlines
From US$324
Copa Airlines
From US$461
Gol Linhas Aereas Inteligentes
From US$1,758
ANA airlines

Find more flights and airlines

Alternative Routes from Santa Cruz to Guayaquil

Discover different routes, airlines, and transfers and find the best alternative flights for your journey from Santa Cruz to Guayaquil.

  • Cheapest
    Avianca
    VVI
    03:05
    20h 30m
    1 transfer
    GYE
    22:35
    Viru Viru International Airport - Jose Joaquin De Olmedo International Airport
    Mon, Jun 10Avianca
    US$254
  • Avianca
    VVI
    03:05
    20h 30m
    1 transfer
    GYE
    22:35
    Viru Viru International Airport - Jose Joaquin De Olmedo International Airport
    Mon, Jun 10Avianca
    US$254
    Find More Flights

Frequently Asked Questions

  • When are flight tickets from Santa Cruz (SRZ) to Guayaquil (GYE) the cheapest?

    Airlines adjust prices for flights from Santa Cruz to Guayaquil based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
  • How much do flights from Santa Cruz (SRZ) to Guayaquil (GYE) cost?

    According to Trip.com's data, the lowest price is around $465.
  • How long does it take to fly from Santa Cruz (SRZ) to Guayaquil (GYE) and what is the distance?

    It takes around 7 hours 5 minutes to fly from Santa Cruz (SRZ) to Guayaquil (GYE).
  • What is the transportation method from the main airport to downtown in Guayaquil?

    • The distance from Jose Joaquin De Olmedo International Airport to downtown is about 4km. It takes about 20 minutes by taxi.
  • What are the most popular airlines that fly from Santa Cruz (SRZ) to Guayaquil (GYE)?

    Airlines with flights from Santa Cruz (SRZ) to Guayaquil (GYE): Avianca.

How to find a cheap flight from Santa Cruz to Guayaquil

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Santa Cruz to Guayaquil. Book your flights at the right time and save more.
1
Book Early
Once prices are gone, they're gone. Lock in deals while you can!
2
Compare Flight Prices
Compare prices on travel agency and airline websites.
3
Look Out for Deals
Check airline and travel agency websites for latest flight deals
4
Check One-way Fares
Buying two cheap one-way flights can sometimes be a better deal than a round-trip.
5
Try Different Dates
Flying during the week, early in the morning, or late at night can help save money.
6
Use the Trip.com App
Save up to £10 per person when booking your flights on Trip.com
Santa Cruz to Guayaquil Flight Information

Cheapest nonstop flight price

$253

Off-season for travel

June

Peak season for travel

July

Flight distance

2,520.59km

Average flight time

7 hours 5 minutes

Popular airline

Avianca