US$181️ Cheap Flights from Mexico City to Santiago (2024)

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Mexico City to Santiago - Flights Starting at US$181

Book one-way or return flights from Mexico City to Santiago from as little as US$181. Choose from the popular airlines below and book your flight today!

One way
Round-trip

Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

We've found these cheap flights for you. You may book a one-way or round trip as per your needs.

We monitor flight fares to help you seize the best deals effortlessly

Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Cheapest airlines flights from Mexico City to Santiago

View airlines operating flights from Mexico City to Santiago. Compare prices, find the option that best suits your travel needs, and enjoy a comfortable journey with a trusted airline.

Copa Airlines

From US$181

American Airlines

From US$306

Volaris

From US$341

Viva Aerobus

From US$361

Avianca

From US$370

Aeromexico

From US$380

United Airlines

From US$392

Air Canada

From US$478

Delta Air Lines

From US$547

ANA airlines

Find more flights and airlines

Alternative Routes from Mexico City to Santiago

Discover different routes, airlines, and transfers and find the best alternative flights for your journey from Mexico City to Santiago.

Cheapest
NLU
14:37
22h 23m
1 transfer
STI
15:00
Felipe Ángeles International Airport - Cibao International Airport
Mon, Jun 3Copa Airlines
US$181
MEX
05:25
8h 10m
1 transfer
STI
15:35
Mexico City International Airport - Cibao International Airport
Sun, Apr 28American Airlines
US$306
MEX
05:25
8h 10m
1 transfer
STI
15:35
Mexico City International Airport - Cibao International Airport
Sun, Apr 28American Airlines
US$306
Find More Flights

Frequently Asked Questions

When are flight tickets from Mexico City (MEX) to Santiago (STI) the cheapest?
Airlines adjust prices for flights from Mexico City to Santiago based on the departure date and time of your selection. By analyzing data from all airlines, we've discovered that on Trip.com, you can find the lowest flight prices on Tuesdays, Wednesdays, and Saturdays.
How much do flights from Mexico City (MEX) to Santiago (STI) cost?
According to Trip.com's data, the lowest price is around $727.
What is the transportation method from the main airport to downtown in Santiago?
- The distance from Cibao International Airport to downtown is about 12km. It takes about 30 minutes by taxi.

How to find a cheap flight from Mexico City to Santiago

Wait until the last minute and flight costs are often sky-high. Plan ahead, book the right way, and your savings can soar. We have loads of saving tips to help you find a cheap flight from Mexico City to Santiago. Book your flights at the right time and save more.

Book Early

Once prices are gone, they're gone. Lock in deals while you can!

Compare Flight Prices

Compare prices on travel agency and airline websites.

Look Out for Deals

Check airline and travel agency websites for latest flight deals

Check One-way Fares

Buying two cheap one-way flights can sometimes be a better deal than a round-trip.

Try Different Dates

Flying during the week, early in the morning, or late at night can help save money.

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