Cheapest airlines flights from Cusco to Santiago

You can choose from 2 airlines that fly from Cusco to Santiago, including LATAM Airlines, JetSMART Airlines, LATAM Airlines has lowest fares on this route.
LATAM Airlines logo LATAM Airlines
JetSMART Airlines logo JetSMART Airlines
Airlines are determined based on actual purchased flight tickets from Cusco to Santiago according to previous 12 months data from Trip.com.

Search for direct flights from Cusco to Santiago in the next 3 months. Based on Trip.com's latest 7-day flight data, one-way direct flights start at US$145, and round-trip direct flights start at US$311.

Displayed flight fares from Cusco to Santiago are based on average prices across airlines for the next 3 months, according to the latest Trip.com database.

Cusco to Santiago Flight Details

The distance between Cusco and Santiago is about 2,211.1 km. The average flying time from Cusco to Santiago is around 2 hours 50 minutes. Based on Trip.com's latest data, travel demand is highest in July. The off-season for travel is December.

Cheapest one-way flight priceUS$103
Cheapest return ticket priceUS$224
Cheapest monthDecember
Peak season for travelJuly
Flight distance2,211.1 km
Average flight time2 hours 50 minutes
Popular airlineLATAM Airlines
Flight statistics for the Cusco–Santiago route are based on aggregated booking data from Trip.com over the past 12 months.

Trip.com Price Insights on Flights from Cusco to Santiago

Which month has the cheapest one-way flights from Cusco to Santiago?

The average price of one-way flights from Cusco to Santiago purchased by Trip.com users by month over the past 12 months.

Based on Trip.com’s data, the cheapest month for flights from Cusco to Santiago is April, with an average price of US$172; while the month with the highest flight price is usually February, with an average price of up to US$456.

US$456
US$314
US$172
US$30
  • US$172
    Apr
  • US$212
    May
  • US$184
    Jun
  • US$263
    Jul
  • US$214
    Aug
  • US$277
    Sep
  • US$241
    Oct
  • US$214
    Nov
  • US$203
    Dec
  • US$279
    Jan
  • US$456
    Feb
  • US$279
    Mar

What is the cheapest day of the week to fly from Cusco to Santiago?

Average weekly flight prices from Cusco to Santiago by travel date (Based on Trip.com’s past 12 months of data)

Based on Trip.com’s past 12 months of flight data, the cheapest day to fly from Cusco to Santiago is Wednesday, with average prices lower than on other days. Avoid Saturday, as prices are usually highest then.

US$311
US$261
US$210
US$160
    Cheapest
  • US$248
    Mon
  • US$257
    Tue
  • US$210
    Wed
  • US$228
    Thu
  • US$258
    Fri
  • US$311
    Sat
  • US$231
    Sun

When is the cheapest day to fly from Cusco to Santiago during International Workers' Day?

Based on Trip.com's data over the past 3 days, these are the lowest one-way flight prices from Cusco to Santiago during International Workers' Day.

International Workers' Day is scheduled for May 1. The cheapest flights from Cusco to Santiago are available on Apr 29, with fares starting at US$127.

US$221
US$174
US$127
US$80
  • US$169
    28
    Apr
  • US$127
    29
  • US$167
    30
  • US$138
    1
    May
  • US$167
    2
  • US$221
    3

Frequently Asked Questions

  • What are the cheapest flights from Cusco to Santiago (CUZ-SCL)?

    Based on Trip.com data, JetSMART Airlines offers one-way fares as low as US$103 on Cheapest nonstop routes (e.g. CUZ to SCL on Mon, Apr 27), while JetSMART Airlines offers Cheapest nonstop round-trips from US$224 departing on Fri, Apr 24 and returning on Sun, Apr 26.
  • At the moment, you can catch a nonstop flight from Cusco to Santiago with the following airlines, including: LATAM Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • It takes about 2 hours 50 minutes to fly from Cusco to Santiago.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Cusco to Santiago is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 9 flight per week flying from Cusco to Santiago. You can check the weekly schedule for popular airlines on this route below: LATAM Airlines: -/-/T/-/T/-/S -- LA2466 (14:51) LATAM Airlines: S/M/T/W/T/F/S -- LA2366 (09:37)
  • To find best deals on flights from Cusco to Santiago, you can use various tools on Trip.com:
    · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Mon, Apr 27, with one-way flights priced at just US$103.
    · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is LATAM Airlines.
    · Set up price alerts to easily monitor ticket prices without having to check every day.
    · Check Trip.com flight deals and promo codes frequently.
    · Avoid peak season unless you book very early. It seems the peak season for Santiago travel is around July.
    · Get exclusive promo codes for Trip.com app users.
  • The cheapest months to fly from Cusco to Santiago is December, when demand for travel is lower.
  • After crunching the numbers on our April flight calendar, it's currently cheapest to fly from Cusco to Santiago on April 23, 2026 with JetSMART, with prices starting at US$97.
  • You can land at any one of the following hubs in Santiago, with Alejandro Velasco Astete International Airport to Arturo Merino Benitez International Airport (CUZ-SCL) is by far the most common option on this route: Arturo Merino Benitez International Airport (SCL).
  • The time difference between Santiago and Cusco is 1h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

Trip.com Airline Insights on Flights from Cusco to Santiago

Which airline offers the cheapest direct flights from Cusco to Santiago?

Data is based on the average price of all nonstop flights from Cusco to Santiago on Trip.com over the past 12 months.

Based on Trip.com’s data from the past 12 months, JetSMART Airlines provides the lowest-priced direct flights from Cusco to Santiago, with fares starting at US$161.

US$128
US$161
US$195
US$228
US$261
JetSMART Airlines
US$161
JetSMART Airlines
avianca
US$209
avianca
Sky Airline
US$229
Sky Airline
LATAM Airlines
US$261
LATAM Airlines

How many flights fly from Cusco to Santiago daily?

The data is based on the flight numbers for each day of the week from Cusco to Santiago within the Trip.com database over the past month.

Based on the past month's historical data from Trip.com, the number of flights from Cusco to Santiago is the highest on Sunday and the lowest on Monday/Tuesday/Thursday.

9
7
4
2
Highest
4
Mon
4
Tue
7
Wed
4
Thu
8
Fri
5
Sat
9
Sun

Note: Prices shown on this page are the estimated lowest prices found in the last 24 hours and include all taxes and fees.

Book with no extra fees

Prices displayed on this page are all-inclusive (incl. taxes, fuel surcharges, Civil Aviation Development Fund, etc.), and all fees are clearly shown before you pay. Charges for checked baggage, onboard meals, Wi‑Fi, and other optional services are also included where applicable in the flight cards.

Real-time pricing updates

Prices, availability, and travel details on this page have been updated within the last 24 hours, and for many routes are refreshed in real time. The more popular the route, the more accurate and up-to-date the data.

Change & Cancellation Policy

Trip.com shows the change and cancellation rules for each ticket during the booking process, including all related fees and conditions. Please refer to the following scenarios:
Voluntary cancellation/change:
To request a change or cancellation, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and flight segment, and submit your request. Please note that additional charges may apply based on the airline’s fare rules.
Cancellation/change due to a flight schedule change:
If your flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For full details of change and cancellation policies, please refer to the customer support pages.