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Flights from Santiago to Antofagasta

Cheapest airlines flights from Santiago to Antofagasta

Fly from Santiago to Antofagasta with 1 carriers, including LATAM Airlines, Sky Airline offers the cheapest flights from Santiago to Antofagasta.
LATAM Airlines logo LATAM Airlines

Non stop flights available! Find direct flights from Santiago to Antofagasta for the next 3 months. Book one way flights from US$18 or round trip tickets from US$31.

      • Cheapest nonstop
        SCL 05:54
        2h 4m
        Nonstop
        ANF 07:58
        Santiago - Antofagasta | Fri, Dec 26 | JetSMART Airlines
        ANF 08:42
        1h 57m
        Nonstop
        SCL 10:39
        Antofagasta - Santiago | Tue, Dec 30 | Sky Airline
        US$31 US$56
        45% OFF
        45% OFF
        US$56 US$31
      • SCL 07:17
        2h 4m
        Nonstop
        ANF 09:21
        Santiago - Antofagasta | Wed, Nov 26 | JetSMART Airlines
        ANF 22:45
        1h 54m
        Nonstop
        SCL 00:39
        Antofagasta - Santiago | Wed, Dec 3 | JetSMART Airlines
        US$33 US$56
        41% OFF
        41% OFF
        US$56 US$33
      • SCL 04:00
        2h 7m
        Nonstop
        ANF 06:07
        Santiago - Antofagasta | Fri, Nov 21 | Sky Airline
        ANF 07:03
        1h 57m
        Nonstop
        SCL 09:00
        Antofagasta - Santiago | Sun, Nov 23 | Sky Airline
        US$36 US$56
        36% OFF
        36% OFF
        US$56 US$36
      • SCL 04:16
        2h 7m
        Nonstop
        ANF 06:23
        Santiago - Antofagasta | Sun, Dec 7 | Sky Airline
        ANF 21:02
        1h 59m
        Nonstop
        SCL 23:01
        Antofagasta - Santiago | Wed, Dec 10 | Sky Airline
        US$37
        34% OFF
        US$56 US$37
      • SCL 04:15
        2h 7m
        Nonstop
        ANF 06:22
        Santiago - Antofagasta | Fri, Nov 28 | Sky Airline
        ANF 23:08
        1h 59m
        Nonstop
        SCL 01:07
        Antofagasta - Santiago | Wed, Dec 3 | Sky Airline
        US$37
        33% OFF
        US$56 US$37
      • SCL 06:08
        2h 4m
        Nonstop
        ANF 08:12
        Santiago - Antofagasta | Sat, Nov 22 | JetSMART Airlines
        ANF 21:20
        1h 59m
        Nonstop
        SCL 23:19
        Antofagasta - Santiago | Sat, Nov 29 | Sky Airline
        US$38
        33% OFF
        US$56 US$38
      • SCL 07:10
        2h 4m
        Nonstop
        ANF 09:14
        Santiago - Antofagasta | Tue, Nov 18 | JetSMART Airlines
        ANF 07:19
        1h 57m
        Nonstop
        SCL 09:16
        Antofagasta - Santiago | Sun, Nov 23 | Sky Airline
        US$38
        32% OFF
        US$56 US$38
      • SCL 05:25
        2h 7m
        Nonstop
        ANF 07:32
        Santiago - Antofagasta | Fri, Dec 26 | Sky Airline
        ANF 08:42
        1h 57m
        Nonstop
        SCL 10:39
        Antofagasta - Santiago | Tue, Dec 30 | Sky Airline
        US$39
        31% OFF
        US$56 US$39
      • SCL 07:00
        2h 4m
        Nonstop
        ANF 09:04
        Santiago - Antofagasta | Fri, Nov 21 | JetSMART Airlines
        ANF 07:03
        1h 57m
        Nonstop
        SCL 09:00
        Antofagasta - Santiago | Sun, Nov 23 | Sky Airline
        US$39
        31% OFF
        US$56 US$39
      • SCL 04:36
        2h 7m
        Nonstop
        ANF 06:43
        Santiago - Antofagasta | Wed, Dec 3 | Sky Airline
        ANF 12:47
        1h 54m
        Nonstop
        SCL 14:41
        Antofagasta - Santiago | Tue, Dec 9 | JetSMART Airlines
        US$39
        30% OFF
        US$56 US$39
      • SCL 13:00
        17h 25m
        1 stop
        ANF Invalid Date
        Santiago - Antofagasta | Thu, Nov 20 | Normal Airline
        ANF 15:00
        6h
        Nonstop
        SCL 16:00
        Antofagasta - Santiago | Sat, Nov 22 | Normal Airline
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Crossed out prices are calculated based on the average price of the corresponding route on Trip.com.

Santiago to Antofagasta Flight Information

The distance between Santiago and Antofagasta is approximately 1,106.73 km. On average, a flight from Santiago to Antofagasta takes around 2 hours 11 minutes. The most popular month to fly to Antofagasta is July. The off-season for travel is October.

Cheapest one-way flight priceUS$18
Cheapest return ticket priceUS$31
Cheapest monthOctober
Peak season for travelJuly
Flight distance1,106.73 km
Average flight time2 hours 11 minutes
Popular airlineLATAM Airlines

When is the cheapest time to book flights from Santiago to Antofagasta?

Best time for cheap flights from Santiago to Antofagasta are between Dec 21 and Dec 28 with one way fares from US$17

Cheapest flights
From price
Search
  • 1623
  • 2330

  • Dec

    307
  • 714
  • 1421
  • 2128

  • Jan

    284
  • 411
  • 1118
  • 1825

  • Feb

    251
  • 18
Displayed prices are calculated based on the cheapest average weekly prices of the corresponding route on Trip.com.

Frequently Asked Questions

  • Which airlines offer direct flights from Santiago to Antofagasta?

    At the moment, you can catch a nonstop flight from Santiago to Antofagasta with the following airlines, including: LATAM Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.
  • It takes about 2 hours 11 minutes to fly from Santiago to Antofagasta.
  • By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Santiago to Antofagasta is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.
  • Based on Trip.com data in the past 4 weeks, there is 100 flight per week flying from Santiago to Antofagasta. You can check the weekly schedule for popular airlines on this route below: LATAM Airlines: S/M/-/W/T/F/S -- LA130 (17:32) LATAM Airlines: S/M/T/W/T/-/- -- LA136 (11:37)
  • The cheapest months to fly from Santiago to Antofagasta is October, when demand for travel is lower.
  • After crunching the numbers on our November flight calendar, it's currently cheapest to fly from Santiago to Antofagasta on November 26, 2025 with Sky Airline, with prices starting at US$17.
  • You can land at any one of the following hubs in Antofagasta, with Arturo Merino Benitez International Airport to Andres Sabella Airport (SCL-ANF) is by far the most common option on this route: Andres Sabella Airport (ANF).
  • The time difference between Antofagasta and Santiago is 0h.
  • Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

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