Cheap Flights from Santiago to La Serena from US$22

Frequently Asked Questions

• What are the cheapest flights from Santiago to La Serena (SCL-LSC)?

  Based on Trip.com data, Sky Airline offers one-way fares as low as US$22 on Cheapest nonstop routes (e.g. SCL to LSC on Wed, Sep 30), while Sky Airline offers Cheapest nonstop round-trips from US$34 departing on Thu, Sep 24 and returning on Sat, Sep 26.

• Which airlines offer direct flights from Santiago to La Serena?

  At the moment, you can catch a nonstop flight from Santiago to La Serena with the following airlines, including: LATAM Airlines Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.

• How long is a flight from Santiago to La Serena?

  It takes about 1 hour 11 minutes to fly from Santiago to La Serena.

• When is the best time to book flights from Santiago to La Serena?

  By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Santiago to La Serena is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

• How many flights are there per week from Santiago to La Serena?

  Based on Trip.com data in the past 4 weeks, there is 51 flight per week flying from Santiago to La Serena. You can check the weekly schedule for popular airlines on this route below: LATAM Airlines: S/M/T/W/T/F/S -- LA100 (06:23)

• How can I find the best deals on flights from Santiago to La Serena?

  To find best deals on flights from Santiago to La Serena, you can use various tools on Trip.com:
  · Be flexible with your travel dates to get the cheapest flight deal. Now the cheapest flight deal is on Wed, Sep 30, with one-way flights priced at just US$22.
  · Compare airlines strategically. Budget carriers often provide the lowest base fares, while we found the most affordable airline currently operating on this route is Sky Airline.
  · Set up price alerts to easily monitor ticket prices without having to check every day.
  · Check Trip.com flight deals and promo codes frequently.
  · Avoid peak season unless you book very early. It seems the peak season for La Serena travel is around July.
  · Get exclusive promo codes for Trip.com app users.

• When are flight tickets from Santiago (SCL) to La Serena (LSC) the cheapest?

  The cheapest months to fly from Santiago to La Serena is October, when demand for travel is lower.

• Which upcoming date is cheapest to fly from Santiago to La Serena on?

  After crunching the numbers on our September flight calendar, it's currently cheapest to fly from Santiago to La Serena on September 18, 2026 with JetSMART, with prices starting at US$19.

• Which airports fly into La Serena from Santiago?

  You can land at any one of the following hubs in La Serena: La Florida Airport (LSC). Flying from Arturo Merino Benitez International Airport to La Florida Airport (SCL-LSC) is by far the most common option on this route.

• Is there any time difference between Santiago and La Serena?

  The time difference between La Serena and Santiago is 0m.

• How do I change or cancel my ticket from Santiago to La Serena?

  Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.

• What is the average cost of a one-way flight from Santiago to La Serena?

  Based on Trip.com data for flights departing in the next 30 days, the average one-way fare from Santiago to La Serena is US$43. Fares vary by travel date, airline and availability.

• What is the average cost of a round-trip flight from Santiago to La Serena?

  Based on Trip.com data for travel in the next 30 days, the average round-trip fare from Santiago to La Serena is US$77. The final price depends on the outbound and return dates, airline and fare conditions.

• How do I book flights from Santiago to La Serena on Trip.com?

  Enter Santiago and La Serena, choose your travel dates and passengers, then compare flights by price, duration and baggage. Select a fare, review the change and cancellation rules, enter traveler details and complete payment to receive your confirmation.

• Are there budget airlines on the Santiago to La Serena route?

  JetSMART and Sky Airlineare the most popular budget airlines flying from Santiago to La Serena. Check baggage, seat and payment fees before comparing the final price.