flight time from Des Moines to San Diego

At the moment, you can catch a nonstop flight from Des Moines to San Diego with the following airlines, including: Allegiant Air Selected airlines are based on historical data collected from flight bookings users made on Trip.com within the last 90 days.

By analyzing data from all airlines on the Trip.com flight calendar, it looks like the best time to book a flight from Des Moines to San Diego is around 40 days (6 weeks) in advance, and the best time to fly is usually on Tuesday, Wednesday, and Saturday. Tuesday typically offers the cheapest flights for departure, while Saturday offers the best return deals.

The cheapest months to fly from Des Moines to San Diego is August, when demand for travel is lower.

After crunching the numbers on our December flight calendar, it's currently cheapest to fly from Des Moines to San Diego on December 23, 2025 with Frontier Airlines, with prices starting at US$80.

You can land at any one of the following hubs in San Diego, with Des Moines International Airport to San Diego International Airport (DSM-SAN) is by far the most common option on this route: McClellan-Palomar Airport (CLD) Marine Corps Air Station Miramar (NKX) San Diego International Airport (SAN).

The time difference between San Diego and Des Moines is 2h.

Tickets can only be changed or canceled if permitted by airline policy. To submit a change or cancellation request, go to the flight bookings page, select the option to change or cancel your booking, choose the relevant passengers and segment, and submit a request. Please note that additional charges may apply according to the airline ticket policy. However, if the flight has been rescheduled and you would like to change or cancel your ticket, you can submit an involuntary cancellation request. For more details about change and cancellation policies, please check the customer support pages.