Hotels in Seneca

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1 king bedWithin 1 kmMotelBreakfast includedGood 7+Entire unitFree cancellationBest WesternSuiteSmoking room
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Wi-Fi in public areasPool24-hour front deskFree parkingBarbecueParking availableGymEV charging stationGolf courseElevatorSmoking areaConference roomLuggage storageWake-up callPets welcome

8 Best Hotels in Seneca

Find great hotels in Seneca on Trip.com! Check guest reviews, latest prices and hotel details to pick your perfect stay.
Top Picks
Lowest Price
Closest to Downtown
Top Reviewed
Best Western Seneca-Clemson Hotels in Seneca
Best Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in SenecaBest Western Seneca-Clemson Hotels in Seneca
44
Hotels in Seneca
"My experience will gyood. The front desk clerk is very kind."
Very Good
102 reviews
8.4/10
1 night
From US$80
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Fairfield Inn & Suites Seneca Clemson Univ Area Hotels in Seneca
Fairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in SenecaFairfield Inn & Suites Seneca Clemson Univ Area Hotels in Seneca
81
Hotels in Seneca
"Very clean, the surrounding environment is also very beautiful, there is also breakfast, a very cost-effective hotel"
Great
78 reviews
9.0/10
1 night
From US$129
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Days Inn by Wyndham Seneca / Clemson Area Hotels in Seneca
Days Inn by Wyndham Seneca / Clemson Area Hotels in SenecaDays Inn by Wyndham Seneca / Clemson Area Hotels in SenecaDays Inn by Wyndham Seneca / Clemson Area Hotels in SenecaDays Inn by Wyndham Seneca / Clemson Area Hotels in SenecaDays Inn by Wyndham Seneca / Clemson Area Hotels in SenecaDays Inn by Wyndham Seneca / Clemson Area Hotels in Seneca
31
Hotels in Seneca
"It was ok, not bad. Would stay again definitely. Could work on amenities. No conditioner toothpaste. But overall it was a pleasure to have stayed"
96 reviews
6.9/10
1 night
From US$73
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Hampton Inn & Suites Seneca-Clemson Area Hotels in Seneca
Hampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in SenecaHampton Inn & Suites Seneca-Clemson Area Hotels in Seneca
99+
Hotels in Seneca
Welcome to the Hampton Inn & Suites Seneca-Clemson Area, a warm and welcoming hotel just a short distance from Lake Keowee and downtown Seneca, SC. Enjoy easy access to local restaurants, state parks, lakes and leisure amenities including golf. Popular Seneca attractions including the Blue Ridge Mountains, the World of Energy and Clemson University are all close to our relaxed hotel in Seneca, SC. Settle in to a beautifully decorated guest room or suite, where you can stay connected with free WiFi at the ergonomic desk, watch the satellite TV and get a great night's sleep on the clean and fresh Hampton bed. Other great amenities include an in-room microwave and refrigerator and guest laundry facilities are available at this Seneca hotel. Every morning, enjoy Hampton's free hot breakfast buffet, offering everything from light continental favorites to hot items and buy snacks at any time from the 24-hour Suite Shop. Enjoy free tea and coffee in the modern lobby, 24-hours a day and ask our friendly staff for advice on what to see and do during your stay. Stay connected with the free business center or hold a meeting in the 600 sq.ft. conference room. Energize in the free fitness center, swim in the outdoor, saltwater pool or relax under an umbrella on the poolside patio area. Friendly service, clean rooms, comfortable surroundings, every time. If you're not satisfied, we don't expect you to pay. That's our commitment and your guarantee. That's 100% Hampton.
Great
96 reviews
9.2/10
1 night
From US$107
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Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson! Hotels in Seneca
Keowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson! Hotels in SenecaKeowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson! Hotels in SenecaKeowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson! Hotels in SenecaKeowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson! Hotels in SenecaKeowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson! Hotels in SenecaKeowee Adventures ~ Peaceful Lakefront Home on Keowee ~ 7 Miles from Clemson! Hotels in Seneca
23
Hotels in Seneca
Escape to a lakeside retreat just 5 minutes from downtown Seneca. Our 3-bedroom, 3-bathroom home offers the perfect place to relax and unwind. Take a dip in the pristine waters of Lake Keowee from our private dock, easily accessible from the backyard. Spend the day exploring the lake with two kayaks at your disposal, or bring your own boat and enjoy water sports all day long, and relax by the fire pit in the evenings.With a fully-equipped kitchen and spacious living area, you can cook up a storm and enjoy meals with family and friends. Dine al fresco on the deck with stunning lake views, or grill out in the backyard for a relaxed outdoor experience. For ultimate privacy, take advantage of the separate downstairs suite with its own private access.Experience lake living at its finest and create memories that will last a lifetime at our serene lakeside oasis. Let your Keowee Adventures begin!About pets:Pets allowed: dogs less than 50 lbs per pet (limit 2 pets total).Certain dog breeds not allowed.About checkOut:Check out before 11:00 AM.About children:Children allowed: ages 0-17.About customRules:No parties or events. Maximum parking 4 vehicles in the driveway. No commercial vehicles. No parking on the street. Certain dog breeds not allowed..About checkIn:Check in after 3:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 25.About events:No events allowed.
Outstanding
9.8/10
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Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson! Hotels in Seneca
Renovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson! Hotels in SenecaRenovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson! Hotels in SenecaRenovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson! Hotels in SenecaRenovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson! Hotels in SenecaRenovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson! Hotels in SenecaRenovated Bungalow 1 Block from Downtown Seneca! 7 miles from Clemson! Hotels in Seneca
32
Hotels in Seneca
Step back in time in this renovated 1940 historic bungalow in downtown Seneca, SC. This charming 3BR, 1.5BA home sleeps 8 and is just steps from Ram Cat Alley's shops and dining. Enjoy a full kitchen, outdoor grill, fully fenced backyard, and a outdoor patio. Only 7 miles from Clemson University—ideal for families or Clemson visits. Close to Lake Keowee, Lake Jocassee, Lake Hartwell, waterfalls, hiking, and Chattooga River whitewater rafting. Your Seneca adventure awaits!**Prime Location:**Downtown Convenience: Steps from shopping, dining, bars, and tap rooms.Close to Clemson University: Only 8 miles away—perfect for game days!Nature at Your Doorstep: Minutes from Lakes Keowee, Jocassee, and Hartwell, plus scenic hiking trails.Golf Nearby: Oconee Country Club is just 3 miles away.**Home Amenities You'll Love:**Comfortable Stay: Three cozy bedrooms and 1.5 bathrooms.Modern Amenities: Fully equipped kitchen, big-screen TV, central AC, and free Wi-Fi.Outdoor Relaxation: Fenced backyard with patio and grill—perfect for unwinding.Ample Parking: Plenty of space for vehicles and boat trailers—ideal for adventure seekers.**Nearby Attractions & Activities:**Outdoor Adventures: Hiking, zip-lining, and whitewater rafting on the Chattooga River.Water Activities: Boating and fishing at Lakes Keowee, Hartwell, and Jocassee.Clemson Tiger Football: Experience the excitement just a short drive away.Community Events: Enjoy local charm with “Jazz on the Alley” from March to October.Book Now to make our charming bungalow your home base for exploring Seneca and Upstate South Carolina. Create unforgettable memories in this vibrant area! Note:Your safety matters. This property features a Ring doorbell device with an exterior security camera facing the front outdoor entry. The camera does not look into any interior spaces. The camera actively records video when motion is detected by the deviceAbout pets:Pets allowed: dogs (limit 2 total).About checkOut:Check out before 11:00 AM.About children:Children allowed: ages 0-17.About customRules:Quiet Hours from 11:00 PM - 7:00 AM. No cats No additional guests or pets without prior approval..About checkIn:Check in after 4:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 18.About events:No events allowed.
Outstanding
10/10
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Beautiful home near Clemson Hotels in Seneca
Beautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in SenecaBeautiful home near Clemson Hotels in Seneca
12
Hotels in Seneca
Convenient to anywhere you would like to be in our area. Less than a mile from shops, restaurants, breweries, Jazz on the Alley, and just 13 minutes away from Clemson University. This home is freshly remodeled throughout with new appliances, furniture, and tv’s as well.About pets:No pets allowed.About checkOut:Check out before 10:00 AM.About children:Children allowed: ages 0-17.About checkIn:Check in after 4:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 22.About events:No events allowed.
Amazing
5 reviews
9.4/10
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The Big Golf House- 10 miles to Clemson Hotels in Seneca
The Big Golf House- 10 miles to Clemson Hotels in SenecaThe Big Golf House- 10 miles to Clemson Hotels in SenecaThe Big Golf House- 10 miles to Clemson Hotels in SenecaThe Big Golf House- 10 miles to Clemson Hotels in SenecaThe Big Golf House- 10 miles to Clemson Hotels in SenecaThe Big Golf House- 10 miles to Clemson Hotels in Seneca
26
Hotels in Seneca
Welcome to your spacious golf course retreat in Seneca, South Carolina, just 15 minutes from Clemson University and minutes from Lake Keowee. This 4,700 sq ft, 4-bedroom, 4-bathroom home is perfect for Clemson football weekends, family gatherings, or lake getaways.Inside, you’ll find room for everyone with multiple living areas, large bedrooms, and four bathrooms. Entertainment is built in with a game room, bar, and private arcade, making the house just as fun to enjoy as the surrounding area. Start your mornings with coffee overlooking the course, and spend your evenings relaxing with family and friends in a private, peaceful setting.Guests love the quiet golf course atmosphere while still being close to everything: Lake Keowee marinas and boat rentals, hiking trails, local dining in downtown Seneca, and Clemson’s stadium.Whether you’re here for game day excitement, a lake adventure, or simply to unwind in a luxury vacation rental, this home combines space, comfort, and location in a way that makes every stay unforgettable.Note:Your safety matters. This property features a Ring doorbell device and flood light that have an exterior security camera facing the front outdoor entry. The camera does not look into any interior spaces. The camera actively records video when motion is detected by the deviceAbout pets:Pets allowed: dogs (limit 2 total).About checkOut:Check out before 11:00 AM.About children:Children allowed: ages 0-17.About checkIn:Check in after 4:00 PM.About smoking:Smoking is not permitted.About minBookingAge:Minimum age to rent: 18.About events:No events allowed.
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Trip.com Hotel Insights for Seneca: Pricing, Trends & Booking Tips

Use Trip.com data-based seasonal trends and best booking times to plan and book your next hotel in Seneca.

What is the cheapest day of the week for hotels in Seneca?

Hotel rates in Seneca are typically lowest on Wednesday, with average nightly rates around US$81. Saturday tends to be the most expensive, averaging US$201 per night.
(Based on Trip.com data from April 28, 2025 to April 28, 2026.)
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Find unique stays in Seneca

Immerse yourself in the vibrant atmosphere of Seneca with our handpicked accommodation options

FAQs about Seneca hotels

What are the best places to stay in Seneca?

Some top places to stay in Seneca are near popular attractions like Bertha Lee Strickland Cultural Museum and South Cove County Park—so you can quickly get to top landmarks and amenities you need.

What hotels in Seneca offer an especially good breakfast?

Which hotels in Seneca provide fitness facilities?

Fairfield Inn & Suites Seneca Clemson Univ Area (price from US$128), Days Inn by Wyndham Seneca / Clemson Area (price from US$62) and Hampton Inn & Suites Seneca-Clemson Area (price from US$134) include fitness facilities, so you can maintain your routine while traveling. Stay on track with your fitness goals while on the go!

Which hotels in Seneca have pools?

Fairfield Inn & Suites Seneca Clemson Univ Area (price from US$128), Best Western Seneca-Clemson (price from US$99) and Days Inn by Wyndham Seneca / Clemson Area (price from US$62) are excellent options for hotels with swimming pools. Book your stay to enjoy the pool and make your trip more enjoyable.

What are the best hotels in Seneca near Bertha Lee Strickland Cultural Museum?

Some standout hotels in Seneca close to Bertha Lee Strickland Cultural Museum include Fairfield Inn & Suites Seneca Clemson Univ Area (price from US$128), Best Western Seneca-Clemson (price from US$99) and Days Inn by Wyndham Seneca / Clemson Area (price from US$62), all within easy walking or transit distance of Bertha Lee Strickland Cultural Museum, perfect for travelers wanting to explore the landmark and its surroundings.

How to get good deals on hotels in Seneca?

Find the best hotel deals and promotions on Trip.com, available year-round for both first-time and loyal users. Please check the promotions page to see what promotions are available now on Trip.com.

More Info about Hotels in Seneca

Number of Reviews
377
Total Properties
8
Weekday Avg. Price
US$147
Weekend Avg. Price
US$207
Trending hotel
Fairfield Inn & Suites Seneca Clemson Univ Area