Frankfurt, officially known as: Frankfurt am Main, is the fifth largest city in Germany and the largest city in Hessen. It is an important industrial, commercial, financial and transportation center in Germany and Europe.  It is located in the Hessen region of western Germany and is located downstream of the Main River, a tributary of central Rhine. Frankfurt has Germany's largest aviation and railway hubs. Frankfurt International Airport (FRA) has become one of the world's most important international airports and air transport hubs, and the third largest airport in Europe after London Heathrow International Airport and Paris Charles de Gaulle International Airport.